TRAF4 and ISYNA1

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		TRAF4	ISYNA1
Description		TNF receptor associated factor 4	inositol-3-phosphate synthase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Bicellular Tight Junction Perinuclear Region Of Cytoplasm Plasma Membrane Receptor Complex	Cytoplasm Cytosol
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding WW Domain Binding	Inositol-3-phosphate Synthase Activity Protein Binding
	Biological Process	Apoptotic Process Activation Of NF-kappaB-inducing Kinase Activity Respiratory Gaseous Exchange Respiratory Tube Development Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Protein K63-linked Ubiquitination	Inositol Biosynthetic Process Phospholipid Biosynthetic Process Inositol Phosphate Metabolic Process
Pathways			Synthesis of IP2, IP, and Ins in the cytosol
Drugs			2-Deoxy-D-Glucitol 6-(E)-Vinylhomophosphonate 2-Deoxy-Glucitol-6-Phosphate Glycerin
Diseases
GWAS			Alzheimer's disease (late onset) ( 30820047) Blood metabolite levels ( 24816252) Breast cancer ( 23535729) Heel bone mineral density ( 30598549)
Interacting Genes		78 interacting genes: ALKBH4 BAHD1 BANP BCKDK BCL6B BEX3 BYSL CALCOCO2 CBL CBLC CCHCR1 CENPE CHUK DTX3 EXOC7 FAM214B FAM90A1 FAT1 FBXL18 FTH1 GOLGA2 GORASP2 GPRASP1 HGS HOMEZ IRAK1 ISYNA1 KANSL1 KDM1A KRT31 KRT40 LTBR MAGEC2 MAGED1 MAP3K4 MRPL28 NCF1 NGFR NOS1AP NPAS2 NTRK1 PDE4DIP PKD1P1 PLSCR1 PSMC3 QARS1 RBPMS REXO1L6P RNF114 RPS6KB1 SIGLEC7 SMURF1 SMURF2 SORBS2 SPDL1 SUMO1 TARBP2 TBC1D7 TBC1D8 TGFB1I1 TICAM1 TNFRSF4 TP53BP2 TRAF6 TRIM37 TYK2 UBE2D1 UBE2I UBL4A UBL4B USP7 WBP11 WWP1 WWP2 ZNF3 ZNF512B ZNF581 ZNF688	4 interacting genes: DUSP14 POT1 PPP2CA TRAF4
Entrez ID		9618	51477
HPRD ID		03915	17163
Ensembl ID		ENSG00000076604	ENSG00000105655
Uniprot IDs		A0A024QZ19 A0A024QZ59 Q9BUZ4	A0A140VK73 Q9NPH2
PDB IDs		2EOD 2YUC 3ZJB 4K8U 4M4E 5YC1
Enriched GO Terms of Interacting Partners?
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