HGS and ATXN1L

Number of citations of the paper that reports this interaction (PubMedID 16713569)
313

Data Source:
BioGRID (two hybrid)

		HGS	ATXN1L
Description		hepatocyte growth factor-regulated tyrosine kinase substrate	ataxin 1 like
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Endosome Early Endosome Cytosol Early Endosome Membrane Multivesicular Body Membrane ESCRT-0 Complex Intracellular Membrane-bounded Organelle Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Dendrite
	Molecular Function	Protein Binding Protein Domain Specific Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding	DNA Binding RNA Binding Protein Binding
	Biological Process	Protein Targeting To Lysosome Signal Transduction Negative Regulation Of Cell Proliferation Membrane Invagination Positive Regulation Of Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Endosomal Transport Macroautophagy Negative Regulation Of Angiogenesis Protein Deubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Multivesicular Body Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of MAP Kinase Activity Negative Regulation Of JAK-STAT Cascade Membrane Organization Protein Localization To Membrane Positive Regulation Of Exosomal Secretion	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Brain Development Learning Memory Extracellular Matrix Organization Social Behavior Lung Alveolus Development Anatomical Structure Development Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways		EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion
Drugs		Citric Acid
Diseases
GWAS		Eye color traits ( 20463881)	Response to anti-TNF therapy in rheumatoid arthritis ( 26776603)
Interacting Genes		182 interacting genes: ABI2 ACLY AHCYL1 APC APLP2 APP ARFIP2 ARL6IP1 ATP1A1 ATP2A2 ATXN1L BCAS2 BEGAIN BRINP3 BSG C1orf94 CASK CBS CCDC103 CCDC114 CCDC136 CCDC33 CDR2 CEP55 CEP57L1 CEP63 CLTC COG8 CRMP1 CRX CSNK2A1 CSTF2 CSTF2T CTTNBP2NL DAZAP2 DCTN2 DECR1 DEUP1 DGCR6 DLG4 DNAJC5 DYDC1 EGFR EHMT2 EPS15 ESRRG EXOC5 EXOC7 EXOC8 FAM168A FANCG FCHSD2 FLOT1 FLOT2 GFAP GFI1B GGA2 GKAP1 GOLGA2 HAP1 HNRNPDL HSFY1 HSPA8 IL2RB IL4R ILKAP ING5 INTS4 JAKMIP2 KIAA0753 KRT13 KRT15 KRT18 KRT19 KRT31 KRT33B KRT38 KRT40 KRT6A KRTAP26-1 LDOC1 LINC00265 LITAF LURAP1 LYST MAGEB4 MAGED1 MAP3K1 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED7 MEST MET MIF4GD MKNK1 MRFAP1L1 MTHFD1L NDC80 NEDD4 NEDD8 NEFL NF2 NMI NPAS2 NUP54 NUP62 OSBPL5 P4HA3 PAK1 PEF1 PELP1 PFKM PIK3R1 PITX1 PLD3 PMEPA1 PNMA1 POGZ PPP1R16A PPP1R7 PTCD3 RBCK1 RFX6 RHOBTB3 RINT1 RPS3A RSU1 SCAMP3 SCRN1 SF3B3 SMAD2 SMAD3 SMAD5 SNAP25 SNX1 SNX5 SNX7 SS18L1 STAM STAM2 STX11 STXBP1 SUMO1 SUN2 SYK TADA2A TASOR2 TEKT1 TFG TIMMDC1 TJP2 TLE5 TMCC2 TOM1L1 TRAF4 TRAK1 TRAP1 TRIM17 TRIM27 TRIM69 TSG101 TUBB TUBB2A UBA1 UBA52 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 USHBP1 VMP1 VPS37A VPS37B VPS37C VPS37D VPS52 ZNF302	57 interacting genes: ACO2 ACOT7 ADORA1 AFAP1L2 ALG13 ANKHD1 AP1G2 AP2M1 APBB1 ATXN1 CAMSAP2 CBFA2T2 CHD6 COIL CTBP1 DAB2 DAZAP2 EPB41L2 EPB41L3 FADS2 FUS GAS7 GMEB2 GORASP2 GPATCH8 HGS HIVEP1 HSFX1 MACROH2A1 MATN2 MBD1 MBD6 MEOX2 METTL17 NBR1 NCOR1 NCOR2 NIT1 PHPT1 PICK1 PRRC2B RAD54L2 RBFOX2 RRAGC SCAF11 SMARCC2 SREBF1 ST6GALNAC6 STAC2 SUGP2 THY1 TMEM25 TMEM8B TRIP11 YY1AP1 ZC3H7B ZSWIM8
Entrez ID		9146	342371
HPRD ID		05085	19555
Ensembl ID		ENSG00000185359	ENSG00000224470
Uniprot IDs		A0A0S2Z4R4 O14964	P0C7T5
PDB IDs		2D3G 3F1I 3OBQ 3ZYQ 4AVX
Enriched GO Terms of Interacting Partners?
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