MAPK8IP1 and MAP2K7

Number of citations of the paper that reports this interaction (PubMedID 10490659)
141

Data Source:
HPRD (in vivo, in vitro)

		MAPK8IP1	MAP2K7
Description		mitogen-activated protein kinase 8 interacting protein 1	mitogen-activated protein kinase kinase 7
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Mitochondrial Membrane Dendritic Growth Cone Axonal Growth Cone Cell Body Dentate Gyrus Mossy Fiber Synapse Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding
	Biological Process	Regulation Of Transcription, DNA-templated Receptor-mediated Endocytosis JUN Phosphorylation Vesicle-mediated Transport Negative Regulation Of JUN Kinase Activity Positive Regulation Of Endocytosis Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Activation Of MAPK Activity Apoptotic Process Response To Osmotic Stress Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Regulation Of Mitotic Cell Cycle Response To Heat Response To UV Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Telomere Maintenance Via Telomerase Response To Tumor Necrosis Factor Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Stress-activated MAPK Cascade Positive Regulation Of Telomerase Activity Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Telomere Capping
Pathways			Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins
Drugs		2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296)	Metabolite levels ( 23823483) Type 2 diabetes ( 30297969)
Interacting Genes		27 interacting genes: AKT1 APP ARHGEF28 DUSP16 EGFR ERBB2 EXOSC8 KLC1 LRP1 LRP2 LRP8 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K7 MAPK8 MAPK8IP2 MAPK8IP3 MAPK9 PARK7 PAX2 RECQL5 SNCA TIAM1 VRK2	32 interacting genes: ARR3 ATF4 CFLAR CNKSR1 DUSP19 DUSP22 GADD45B JUN LPXN LRRK2 MAP3K1 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MAPT RANBP2 RPL30 TRAF6 TRIB1 VRK2
Entrez ID		9479	5609
HPRD ID		05223	04309
Ensembl ID		ENSG00000121653	ENSG00000076984
Uniprot IDs		Q6NUQ9 Q9UQF2	B4DV95 O14733
PDB IDs		2G01 2GMX 2H96 3OXI 3PTG 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4E73 4G1W 4H39 4HYS 4HYU 4IZY 5LW1 6FUZ	2DYL 3WZU 4UX9 5B2K 5B2L 5B2M 5Y8U 5Y90 5Z1D 5Z1E 6IB0 6IB2 6QFL 6QFR 6QFT 6QG4 6QG7 6QHO 6QHR
Enriched GO Terms of Interacting Partners?
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