MAP2K7 and RANBP2

Number of citations of the paper that reports this interaction (PubMedID 26364603)
4

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		MAP2K7	RANBP2
Description		mitogen-activated protein kinase kinase 7	RAN binding protein 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nuclear Envelope Annulate Lamellae Nuclear Pore Cytoplasm Mitochondrion Cytosol Membrane Nuclear Membrane Nuclear Inclusion Body Intracellular Membrane-bounded Organelle Host Cell Nuclear Pore Cytoplasmic Filaments Nuclear Pore Nuclear Basket Cytoplasmic Periphery Of The Nuclear Pore Complex
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity GTPase Activator Activity Protein Binding Ran GTPase Binding Cyclosporin A Binding SUMO Transferase Activity Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Activation Of MAPK Activity Apoptotic Process Response To Osmotic Stress Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Regulation Of Mitotic Cell Cycle Response To Heat Response To UV Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Telomere Maintenance Via Telomerase Response To Tumor Necrosis Factor Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Stress-activated MAPK Cascade Positive Regulation Of Telomerase Activity Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Telomere Capping	Protein Peptidyl-prolyl Isomerization Response To Amphetamine Regulation Of Glycolytic Process Regulation Of Gluconeogenesis MRNA Export From Nucleus TRNA Export From Nucleus Protein Folding NLS-bearing Protein Import Into Nucleus Viral Process Protein Sumoylation Viral Transcription Positive Regulation Of Glucokinase Activity Positive Regulation Of GTPase Activity Centrosome Localization Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat
Pathways		Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins	ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Type 2 diabetes ( 30297969)	Attention deficit hyperactivity disorder ( 29325848) Beard thickness ( 26926045) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045)
Interacting Genes		32 interacting genes: ARR3 ATF4 CFLAR CNKSR1 DUSP19 DUSP22 GADD45B JUN LPXN LRRK2 MAP3K1 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MAPT RANBP2 RPL30 TRAF6 TRIB1 VRK2	35 interacting genes: AKAP13 ARID4B CALM1 CDCA8 CUL1 FHOD1 GCC2 HDAC4 IFT140 IPO5 KPNA1 KPNA2 KPNB1 LRPAP1 MAP2K7 MDM2 NUP62 NXF1 OPN1LW OPN1MW PRKN RAN RANGAP1 SENP1 SP100 SUMO1 SUMO2 TAF1 TNPO1 TOP2B UBE2I UBTD1 WAS XPO1 XPOT
Entrez ID		5609	5903
HPRD ID		04309	03111
Ensembl ID		ENSG00000076984	ENSG00000153201
Uniprot IDs		B4DV95 O14733	P49792
PDB IDs		2DYL 3WZU 4UX9 5B2K 5B2L 5B2M 5Y8U 5Y90 5Z1D 5Z1E 6IB0 6IB2 6QFL 6QFR 6QFT 6QG4 6QG7 6QHO 6QHR	1RRP 1XKE 1Z5S 2LAS 3UIN 3UIO 3UIP 4GA0 4I9Y 4L6E 4LQW 5CLL 5CLQ
Enriched GO Terms of Interacting Partners?
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