MAP2K7 and DUSP22

Number of citations of the paper that reports this interaction (PubMedID 12138158)
28

Data Source:
HPRD (in vivo, in vitro)

		MAP2K7	DUSP22
Description		mitogen-activated protein kinase kinase 7	dual specificity phosphatase 22
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Plasma Membrane Filamentous Actin Leading Edge Of Lamellipodium
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine Kinase Binding
	Biological Process	Activation Of MAPK Activity Apoptotic Process Response To Osmotic Stress Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Regulation Of Mitotic Cell Cycle Response To Heat Response To UV Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Telomere Maintenance Via Telomerase Response To Tumor Necrosis Factor Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Stress-activated MAPK Cascade Positive Regulation Of Telomerase Activity Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Telomere Capping	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of T Cell Mediated Immunity Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Regulation Of Cell Proliferation Positive Regulation Of JNK Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Focal Adhesion Assembly Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity
Pathways		Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Type 2 diabetes ( 30297969)	Albumin-globulin ratio ( 29403010) Alopecia areata ( 25608926) Asthma (childhood onset) ( 31036433) Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Male-pattern baldness ( 28196072) Non-albumin protein levels ( 29403010) Serum total protein level ( 29403010) Takayasu arteritis ( 30498034)
Interacting Genes		32 interacting genes: ARR3 ATF4 CFLAR CNKSR1 DUSP19 DUSP22 GADD45B JUN LPXN LRRK2 MAP3K1 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MAPT RANBP2 RPL30 TRAF6 TRIB1 VRK2	5 interacting genes: HOXA1 MAP2K4 MAP2K7 MAPK14 MAPK8
Entrez ID		5609	56940
HPRD ID		04309	13255
Ensembl ID		ENSG00000076984	ENSG00000112679
Uniprot IDs		B4DV95 O14733	A0A384NLC8 Q9NRW4
PDB IDs		2DYL 3WZU 4UX9 5B2K 5B2L 5B2M 5Y8U 5Y90 5Z1D 5Z1E 6IB0 6IB2 6QFL 6QFR 6QFT 6QG4 6QG7 6QHO 6QHR	1WRM 4WOH
Enriched GO Terms of Interacting Partners?
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