ARHGEF6 and GPRASP2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		ARHGEF6	GPRASP2
Description		Rac/Cdc42 guanine nucleotide exchange factor 6	G protein-coupled receptor associated sorting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Lamellipodium	Nucleus Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Amyloid-beta Binding G Protein-coupled Receptor Binding Protein Binding
	Biological Process	Apoptotic Process G Protein-coupled Receptor Signaling Pathway JNK Cascade Lamellipodium Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42
Drugs
Diseases		Non-syndromic X-linked mental retardation
GWAS		Breast cancer ( 29059683)
Interacting Genes		24 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CDC42 EPHB2 GIT1 GPRASP2 PAK1 PAK2 PAK3 PARVB SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 YWHAG ZNF580	29 interacting genes: ADRB1 ARHGEF6 BARD1 CALCR CBX8 CEP126 CFAP206 CHRM1 CHRM2 DISC1 FRAT1 HAP1 HRH2 HTR7 HTT LRIF1 MICU2 MYOT NOL4L-DT PRPF3 PTN RPS6KA5 RTL10 STMN2 TCF25 TSPOAP1 TXN TXN2 ZNF688
Entrez ID		9459	114928
HPRD ID		02226	06612
Ensembl ID		ENSG00000129675	ENSG00000158301
Uniprot IDs		B7Z3C7 Q15052 Q8N4Q3	B3KW05 Q96D09
PDB IDs		1UJY 1WYR
Enriched GO Terms of Interacting Partners?
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