ARHGEF6 and ZNF580

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		ARHGEF6	ZNF580
Description		Rac/Cdc42 guanine nucleotide exchange factor 6	zinc finger protein 580
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Lamellipodium	Nuclear Chromatin Nucleus Nucleoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Apoptotic Process G Protein-coupled Receptor Signaling Pathway JNK Cascade Lamellipodium Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Leukocyte Chemotaxis Regulation Of Transcription By RNA Polymerase II Chemotaxis Inflammatory Response Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Positive Regulation Of Interleukin-8 Production Cellular Response To Hydrogen Peroxide
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42
Drugs
Diseases		Non-syndromic X-linked mental retardation
GWAS		Breast cancer ( 29059683)
Interacting Genes		24 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CDC42 EPHB2 GIT1 GPRASP2 PAK1 PAK2 PAK3 PARVB SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 YWHAG ZNF580	6 interacting genes: ARHGEF6 PAX9 RAD54B SH3GL2 TSC22D4 XBP1
Entrez ID		9459	51157
HPRD ID		02226	18353
Ensembl ID		ENSG00000129675	ENSG00000213015
Uniprot IDs		B7Z3C7 Q15052 Q8N4Q3	Q9UK33
PDB IDs		1UJY 1WYR
Enriched GO Terms of Interacting Partners?
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