ARHGEF6 and TMEM108

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		ARHGEF6	TMEM108
Description		Rac/Cdc42 guanine nucleotide exchange factor 6	transmembrane protein 108
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Lamellipodium	Cellular_component Early Endosome Endosome Membrane Postsynaptic Density Integral Component Of Membrane Cell Junction Axon Dendrite Somatodendritic Compartment Axon Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Molecular_function
	Biological Process	Apoptotic Process G Protein-coupled Receptor Signaling Pathway JNK Cascade Lamellipodium Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Receptor-mediated Endocytosis Retrograde Axonal Transport Biological_process Dentate Gyrus Development Neuron Projection Development Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Postsynaptic Density Organization Dendrite Extension Modulation Of Excitatory Postsynaptic Potential Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42
Drugs
Diseases		Non-syndromic X-linked mental retardation
GWAS		Breast cancer ( 29059683)	Chronotype ( 30696823) IgE grass sensitization ( 22036096) Iron status biomarkers (total iron binding capacity) ( 28334935) Menarche (age at onset) ( 27182965 21102462) Systolic blood pressure ( 30224653 30578418) Waist circumference ( 28552196)
Interacting Genes		24 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CDC42 EPHB2 GIT1 GPRASP2 PAK1 PAK2 PAK3 PARVB SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 YWHAG ZNF580	4 interacting genes: ANXA7 ARHGEF6 NOTCH3 SH3GL2
Entrez ID		9459	66000
HPRD ID		02226	11329
Ensembl ID		ENSG00000129675	ENSG00000144868
Uniprot IDs		B7Z3C7 Q15052 Q8N4Q3	B3KT64 Q6UXF1
PDB IDs		1UJY 1WYR
Enriched GO Terms of Interacting Partners?
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