SLC9A3R2 and LPAR1

Number of citations of the paper that reports this interaction (PubMedID 16203867)
65

Data Source:
HPRD (in vitro)

		SLC9A3R2	LPAR1
Description		SLC9A3 regulator 2	lysophosphatidic acid receptor 1
Image
GO Annotations	Cellular Component	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Apical Plasma Membrane Extracellular Exosome	Cell Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle Neuronal Cell Body Dendritic Spine Dendritic Shaft
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Phosphatase Binding Cadherin Binding Molecular Adaptor Activity	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Protein Binding PDZ Domain Binding Lysophosphatidic Acid Binding Lysophosphatidic Acid Receptor Activity
	Biological Process	Protein-containing Complex Assembly	Activation Of MAPK Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cell Shape Negative Regulation Of Neuron Projection Development Oligodendrocyte Development Cerebellum Development Optic Nerve Development Corpus Callosum Development Bleb Assembly Positive Regulation Of Rho Protein Signal Transduction Myelination Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Stress Fiber Assembly Cell Chemotaxis Positive Regulation Of Dendritic Spine Development Cellular Response To Oxygen Levels Positive Regulation Of Smooth Muscle Cell Chemotaxis Cellular Response To 1-oleoyl-sn-glycerol 3-phosphate
Pathways			G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878 30578418) Pulse pressure ( 30578418) Systolic blood pressure ( 27841878 30578418)	Birth weight ( 31043758 27680694) Central corneal thickness ( 31798171 29760442 30894546) Corneal structure ( 23291589) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Height ( 20881960 25282103 31562340) Monocyte count ( 28193307 29403010) Neutrophil percentage of granulocytes ( 27863252) Offspring birth weight ( 31043758) Post bronchodilator FEV1 in COPD ( 26634245) Pursuit maintenance gain ( 29064472) Sum eosinophil basophil counts ( 27863252) White blood cell count (monocyte) ( 28158719)
Interacting Genes		37 interacting genes: ABCC4 ACTN4 ADORA2B ADRB2 ATP2B2 CFTR EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAZ TBC1D10A WWTR1	6 interacting genes: ARHGEF11 ARHGEF12 GIPC1 GNAI3 KRAS SLC9A3R2
Entrez ID		9351	1902
HPRD ID		05946	03790
Ensembl ID		ENSG00000065054	ENSG00000198121
Uniprot IDs		Q15599	Q5VZX0 Q92633
PDB IDs		2D11 2HE4 2OCS 4P0C	4Z34 4Z35 4Z36
Enriched GO Terms of Interacting Partners?
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