TOB2 and CNOT8

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TOB2	CNOT8
Description		transducer of ERBB2, 2	CCR4-NOT transcription complex subunit 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	P-body Intracellular Nucleus Cytosol CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Vitamin D Receptor Binding	3'-5'-exoribonuclease Activity DNA-binding Transcription Factor Activity RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Metal Ion Binding
	Biological Process	Female Gamete Generation Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Ossification Negative Regulation Of Nucleic Acid-templated Transcription	Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cell Proliferation Negative Regulation Of Translation Gene Silencing By MiRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310) Autism spectrum disorder or schizophrenia ( 28540026) Neuroticism ( 29255261) Vitiligo ( 22561518)
Interacting Genes		5 interacting genes: BHLHE40 CEP76 CNOT7 CNOT8 RPS6KA1	9 interacting genes: BTG1 BTG2 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 PRMT1 TOB2
Entrez ID		10766	9337
HPRD ID		09583	07225
Ensembl ID		ENSG00000183864	ENSG00000155508
Uniprot IDs		Q14106	B7Z9U0 Q9UFF9
PDB IDs
Enriched GO Terms of Interacting Partners?
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