CD22 and LCP2

Number of citations of the paper that reports this interaction (PubMedID 15668918)
7

Data Source:
HPRD (in vitro)

		CD22	LCP2
Description		CD22 molecule	lymphocyte cytosolic protein 2
Image
GO Annotations	Cellular Component	Cytoplasm Early Endosome Plasma Membrane Cell Surface Integral Component Of Membrane Neuronal Cell Body Membrane Recycling Endosome Extracellular Exosome	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft
	Molecular Function	IgM Binding Signaling Receptor Binding Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding CD4 Receptor Binding	Protein Binding
	Biological Process	Cell Adhesion Regulation Of Endocytosis Regulation Of B Cell Proliferation B Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Immunoglobulin Secretion	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Mast Cell Activation Positive Regulation Of Protein Kinase Activity Cytokine Secretion T Cell Receptor Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs		Epratuzumab Inotuzumab ozogamicin
Diseases
GWAS			Acne (severe) ( 24927181) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		17 interacting genes: AP2M1 ATP2B4 CD19 GRB2 HP IGHM INPP5D LCP2 LYN MTDH PIK3R1 PLCG1 PTPN6 PTPRC SHC1 ST6GAL1 SYK	43 interacting genes: APP BLNK CBL CD22 CLNK EGFR FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LARP1 LAT LCK LMNA LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70
Entrez ID		933	3937
HPRD ID		00114	03362
Ensembl ID		ENSG00000012124	ENSG00000043462
Uniprot IDs		P20273 Q0EAF5	Q13094
PDB IDs		5VKJ 5VKM 5VL3	1H3H 1YWO 2EAP 2ROR
Enriched GO Terms of Interacting Partners?
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