FRS3 and SOCS6

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		FRS3	SOCS6
Description		fibroblast growth factor receptor substrate 3	suppressor of cytokine signaling 6
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GO Annotations	Cellular Component	Plasma Membrane	Immunological Synapse Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	MAPK Cascade Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway	Defense Response JAK-STAT Cascade Negative Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Phosphatidylinositol Phosphorylation Negative Regulation Of T Cell Activation
Pathways		FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3	Regulation of KIT signaling Neddylation
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870)	Diverticular disease ( 30177863) Night sleep phenotypes ( 27126917) Systemic lupus erythematosus ( 18204098) Type 2 diabetes ( 29621232)
Interacting Genes		28 interacting genes: ADAMTSL4 BMPR2 CBY2 DDX5 FGFR1 GATA1 GRB14 GRB2 KARS1 MAPK1 MATK NOTCH2NLA NTRK1 NTRK2 NUMB PLSCR1 PRKCI PTPN11 RFX6 RND1 SH2B1 SOCS6 SPRY2 TCF4 TLE5 TNS1 TRIP6 VASP	31 interacting genes: ACVR1 APPL1 BMPR1B CLNK CRK DAB1 EFEMP1 EGFR ELOB ELOC FRS3 INSR IRS2 IRS4 KDM1A KIT LNX1 PIK3R1 PIK3R2 PIK3R3 PITRM1 RBCK1 RELA SMURF2 TGFBR1 TUBA1A TUBB4B UBE2D2 UBE2I WDR89 ZMIZ2
Entrez ID		10817	9306
HPRD ID		06373	05491
Ensembl ID		ENSG00000137218	ENSG00000170677
Uniprot IDs		A0A140VJJ7 O43559	A0A024R379 O14544
PDB IDs		2KUP 2KUQ 2YS5 2YT2	2VIF
Enriched GO Terms of Interacting Partners?
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