VAPB and STX5

Number of citations of the paper that reports this interaction (PubMedID 12651853)
5

Data Source:
BioGRID (pull down)

		VAPB	STX5
Description		VAMP associated protein B and C	syntaxin 5
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GO Annotations	Cellular Component	Golgi Membrane Cell Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Endoplasmic Reticulum Exit Site	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endomembrane System ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane SNARE Complex Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Beta-tubulin Binding	SNARE Binding SNAP Receptor Activity Protein Binding Cadherin Binding Protein N-terminus Binding
	Biological Process	Cellular Calcium Ion Homeostasis ER To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Modulation By Virus Of Host Morphology Or Physiology Sphingolipid Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response IRE1-mediated Unfolded Protein Response Positive Regulation Of Viral Genome Replication Endoplasmic Reticulum-plasma Membrane Tethering COPII-coated Vesicle Budding Endoplasmic Reticulum Membrane Organization	Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Vesicle Fusion Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of Protein Catabolic Process COPII Vesicle Coating Vesicle Docking Vesicle Fusion With Golgi Apparatus Golgi Disassembly Regulation Of Golgi Organization
Pathways		Sphingolipid de novo biosynthesis	COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport Intra-Golgi traffic Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS			Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		16 interacting genes: AQP2 EMD GLP1R GPR25 KCNB1 MTNR1A OSBPL2 STX1A STX2 STX4 STX5 USP20 VAMP1 VAMP2 VHL VKORC1	29 interacting genes: APLP1 BAG6 BET1 COPS6 GET3 GOSR1 GOSR2 HAP1 IMMT KASH5 LMNA LNX1 LRIF1 MAGEA6 NAPA NAPB NSFL1C SCFD1 SEC22B SNAP23 SNAP25 STX4 STXBP1 TACC1 TP53 USO1 VAPB VCP VCPIP1
Entrez ID		9217	6811
HPRD ID		09300	04426
Ensembl ID		ENSG00000124164	ENSG00000162236
Uniprot IDs		O95292 Q53XM7	B4DKR0 Q13190
PDB IDs		2MDK 3IKK	3EFO
Enriched GO Terms of Interacting Partners?
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