VAPB and VAMP2

Number of citations of the paper that reports this interaction (PubMedID 9920726)
49

Data Source:
HPRD (in vitro)

		VAPB	VAMP2
Description		VAMP associated protein B and C	vesicle associated membrane protein 2
Image
GO Annotations	Cellular Component	Golgi Membrane Cell Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Endoplasmic Reticulum Exit Site	Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Cell Junction Clathrin-coated Vesicle Secretory Granule Clathrin-coated Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Vesicle Zymogen Granule Membrane Neuron Projection Intracellular Membrane-bounded Organelle Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Clathrin-sculpted Monoamine Transport Vesicle Membrane
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Beta-tubulin Binding	SNARE Binding SNAP Receptor Activity Protein Binding Calmodulin Binding Phospholipid Binding Syntaxin-1 Binding Syntaxin Binding Protein Self-association Calcium-dependent Protein Binding
	Biological Process	Cellular Calcium Ion Homeostasis ER To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Modulation By Virus Of Host Morphology Or Physiology Sphingolipid Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response IRE1-mediated Unfolded Protein Response Positive Regulation Of Viral Genome Replication Endoplasmic Reticulum-plasma Membrane Tethering COPII-coated Vesicle Budding Endoplasmic Reticulum Membrane Organization	Exocytosis Post-Golgi Vesicle-mediated Transport Vesicle Fusion Neurotransmitter Secretion Response To Glucose Glutamate Secretion Protein Transport Synaptic Vesicle Exocytosis Vesicle-mediated Transport Calcium Ion Regulated Exocytosis Regulation Of Exocytosis Cellular Response To Insulin Stimulus SNARE Complex Assembly Golgi To Plasma Membrane Protein Transport Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Long-term Synaptic Potentiation Regulation Of Vesicle-mediated Transport Membrane Organization Membrane Fusion Protein-containing Complex Assembly Mucus Secretion Positive Regulation Of Intracellular Protein Transport Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Histamine Secretion By Mast Cell
Pathways		Sphingolipid de novo biosynthesis	Translocation of SLC2A4 (GLUT4) to the plasma membrane Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle trans-Golgi Network Vesicle Budding Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Other interleukin signaling Toxicity of botulinum toxin type D (BoNT/D) Toxicity of botulinum toxin type B (BoNT/B) Toxicity of botulinum toxin type F (BoNT/F) Toxicity of tetanus toxin (TeNT) Toxicity of botulinum toxin type G (BoNT/G) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs			Botulinum Toxin Type B
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS			Chronotype ( 30696823) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Morning person ( 30696823) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		16 interacting genes: AQP2 EMD GLP1R GPR25 KCNB1 MTNR1A OSBPL2 STX1A STX2 STX4 STX5 USP20 VAMP1 VAMP2 VHL VKORC1	28 interacting genes: ATP13A2 BAG6 BCAP31 CPLX1 EXOC3 FKBP2 GET3 LMNA PRKD3 RABAC1 SLC6A4 SNAP23 SNAP25 SNAP29 STX11 STX1A STX1B STX4 STXBP2 STXBP3 SYP SYPL1 TRPC3 VAMP3 VAMP8 VAPA VAPB VCP
Entrez ID		9217	6844
HPRD ID		09300	01717
Ensembl ID		ENSG00000124164	ENSG00000220205
Uniprot IDs		O95292 Q53XM7	F8WCA0 P63027
PDB IDs		2MDK 3IKK	3FIE 3FII 3RK2 3RK3 3RL0
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?