VAPB and GPR25

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		VAPB	GPR25
Description		VAMP associated protein B and C	G protein-coupled receptor 25
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cell Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Endoplasmic Reticulum Exit Site	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Beta-tubulin Binding	G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Cellular Calcium Ion Homeostasis ER To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Modulation By Virus Of Host Morphology Or Physiology Sphingolipid Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response IRE1-mediated Unfolded Protein Response Positive Regulation Of Viral Genome Replication Endoplasmic Reticulum-plasma Membrane Tethering COPII-coated Vesicle Budding Endoplasmic Reticulum Membrane Organization	G Protein-coupled Receptor Signaling Pathway
Pathways		Sphingolipid de novo biosynthesis	G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS			Ankylosing spondylitis ( 23749187)
Interacting Genes		16 interacting genes: AQP2 EMD GLP1R GPR25 KCNB1 MTNR1A OSBPL2 STX1A STX2 STX4 STX5 USP20 VAMP1 VAMP2 VHL VKORC1	9 interacting genes: CREB3L1 FATE1 GGT7 KASH5 LMNA MAP3K7 NAALADL2 PNMA1 VAPB
Entrez ID		9217	2848
HPRD ID		09300	03707
Ensembl ID		ENSG00000124164	ENSG00000170128
Uniprot IDs		O95292 Q53XM7	O00155
PDB IDs		2MDK 3IKK
Enriched GO Terms of Interacting Partners?
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