MAP3K8 and RIPK1

Number of citations of the paper that reports this interaction (PubMedID 16291755)
6

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MAP3K8	RIPK1
Description		mitogen-activated protein kinase kinase kinase 8	receptor interacting serine/threonine kinase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Mitochondrion Cytosol Endosome Membrane Death-inducing Signaling Complex Protein-containing Complex Receptor Complex Membrane Raft Ripoptosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Death Receptor Binding Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Death Domain Binding
	Biological Process	Activation Of MAPKK Activity Protein Phosphorylation Cell Cycle Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade T Cell Costimulation Activation Of Protein Kinase Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway	Positive Regulation Of Protein Phosphorylation MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process I-kappaB Kinase/NF-kappaB Signaling Activation Of JNKK Activity Activation Of JUN Kinase Activity Cell Death Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Necrotic Cell Death Viral Process Protein Deubiquitination Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 3 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway Peptidyl-serine Autophosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Catabolic Process Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Necroptotic Process T Cell Apoptotic Process Necroptotic Process Cellular Response To Hydrogen Peroxide Regulation Of ATP:ADP Antiporter Activity Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Death-inducing Signaling Complex Assembly Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Programmed Necrotic Cell Death Ripoptosome Assembly Necroptotic Signaling Pathway Ripoptosome Assembly Involved In Necroptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Hydrogen Peroxide-induced Cell Death Amyloid Fibril Formation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation	Caspase activation via Death Receptors in the presence of ligand TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Regulation of necroptotic cell death Ub-specific processing proteases Ovarian tumor domain proteases Dimerization of procaspase-8 TNF signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IKK complex recruitment mediated by RIP1
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)	Cerebral white matter volume ( 31530798) Depressive symptoms x independent stressful life events interaction (1df test) ( 30718454) Depressive symptoms x independent stressful life events interaction (2df test) ( 30718454) Idiopathic osteonecrosis of the femoral head ( 28000841)
Interacting Genes		17 interacting genes: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6	53 interacting genes: BIRC3 CASP8 CCDC50 CDC42BPB CFLAR CRADD EGFR FADD FAS GMPR H2BC13 HSP90AA1 IKBKB IKBKE IKBKG ITCH MAP3K1 MAP3K14 MAP3K3 MAP3K8 MTDH NFKB1 NUMBL OTUD1 PDXK PELI1 PRPF4B PTK2 PXDC1 RIPK3 RNF11 RNF216 SQSTM1 TAX1BP1 TBK1 TICAM1 TNF TNFAIP3 TNFRSF10A TNFRSF10B TNFRSF1A TRADD TRAF1 TRAF2 TRAF3 TRAF5 TRIM38 TRPC4AP UBE2N WRNIP1 YOD1 ZFAND5 ZNHIT1
Entrez ID		1326	8737
HPRD ID		01863	04583
Ensembl ID		ENSG00000107968	ENSG00000137275
Uniprot IDs		P41279 Q6FG25	A0A024QZU0 Q13546
PDB IDs		4Y83 4Y85 5IU2	4ITH 4ITI 4ITJ 4NEU 5HX6 5TX5 5V7Z 6AC5 6C3E 6C4D 6HHO 6NW2 6NYH 6OCQ 6R5F 6RLN
Enriched GO Terms of Interacting Partners?
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