MAP3K8 and STIP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MAP3K8	STIP1
Description		mitogen-activated protein kinase kinase kinase 8	stress induced phosphoprotein 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Golgi Apparatus Cytosol Protein-containing Complex Chaperone Complex
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding	RNA Binding Protein Binding Protein C-terminus Binding Hsp70 Protein Binding Chaperone Binding Hsp90 Protein Binding
	Biological Process	Activation Of MAPKK Activity Protein Phosphorylation Cell Cycle Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade T Cell Costimulation Activation Of Protein Kinase Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway	Cellular Response To Interleukin-7
Pathways		CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation	HSP90 chaperone cycle for steroid hormone receptors (SHR)
Drugs			Copper
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)	Attention deficit hyperactivity disorder ( 21784300) Crohn's disease ( 28067908)
Interacting Genes		17 interacting genes: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6	22 interacting genes: ACD ACVR1 AIP APP CDC37 CLCN1 CLK1 EGFR FKBP4 FKBP5 HSP90AA1 HSPA14 HSPA1A HSPA8 LMO2 LRRK2 MAP3K8 POT1 PRNP PTGES3 SUMO4 YIF1A
Entrez ID		1326	10963
HPRD ID		01863	05454
Ensembl ID		ENSG00000107968	ENSG00000168439
Uniprot IDs		P41279 Q6FG25	P31948 V9HW72
PDB IDs		4Y83 4Y85 5IU2	1ELR 1ELW 2LNI 2NC9 3ESK 3FWV
Enriched GO Terms of Interacting Partners?
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