ATXN1L and DAB2

Number of citations of the paper that reports this interaction (PubMedID 16713569)
313

Data Source:
BioGRID (two hybrid)

		ATXN1L	DAB2
Description		ataxin 1 like	DAB adaptor protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Dendrite	Fibrillar Center Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Focal Adhesion Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding RNA Binding Protein Binding	Protein Binding Protein C-terminus Binding Clathrin Adaptor Activity Cargo Receptor Activity SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Brain Development Learning Memory Extracellular Matrix Organization Social Behavior Lung Alveolus Development Anatomical Structure Development Positive Regulation Of Hematopoietic Stem Cell Proliferation	Positive Regulation Of Protein Phosphorylation Receptor-mediated Endocytosis Apoptotic Process Integrin-mediated Signaling Pathway Multicellular Organism Development Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Protein Transport Wnt Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Leading Edge Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway Membrane Organization Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways			Gap junction degradation Formation of annular gap junctions Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Response to anti-TNF therapy in rheumatoid arthritis ( 26776603)	Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Aspartate aminotransferase levels ( 29403010) Birth weight ( 31043758) Chronic kidney disease ( 31152163 20383146) Creatinine levels ( 31015462) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Health literacy ( 31250787) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Non-albumin protein levels ( 29403010) Pancreatic cancer ( 22158540) Premature menopause in childhood cancer survivors ( 29432556) Self-reported allergy ( 23817569) Systemic lupus erythematosus ( 19838195) Urate levels ( 23263486) Waist-hip ratio ( 28552196)
Interacting Genes		57 interacting genes: ACO2 ACOT7 ADORA1 AFAP1L2 ALG13 ANKHD1 AP1G2 AP2M1 APBB1 ATXN1 CAMSAP2 CBFA2T2 CHD6 COIL CTBP1 DAB2 DAZAP2 EPB41L2 EPB41L3 FADS2 FUS GAS7 GMEB2 GORASP2 GPATCH8 HGS HIVEP1 HSFX1 MACROH2A1 MATN2 MBD1 MBD6 MEOX2 METTL17 NBR1 NCOR1 NCOR2 NIT1 PHPT1 PICK1 PRRC2B RAD54L2 RBFOX2 RRAGC SCAF11 SMARCC2 SREBF1 ST6GALNAC6 STAC2 SUGP2 THY1 TMEM25 TMEM8B TRIP11 YY1AP1 ZC3H7B ZSWIM8	39 interacting genes: AP2M1 APLP1 APLP2 APP ATXN1L AXIN1 CDC16 CDK1 CSK DAB2IP DIP2A DVL1 DVL3 FCHO1 FCHO2 FGR GRB2 INPP5D ITGB3 ITGB5 ITSN1 LDLR LRP1 LRP2 LRP8 MIB1 MYO6 NECAP1 PIN1 PRKCB PRKCD PRKCG SGIP1 SMAD2 SMAD3 SMURF2 SRC TGFBR1 TGFBR2
Entrez ID		342371	1601
HPRD ID		19555	03139
Ensembl ID		ENSG00000224470	ENSG00000153071
Uniprot IDs		P0C7T5	A0A024R036 B2RAW0 P98082
PDB IDs			2LSW
Enriched GO Terms of Interacting Partners?
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