CD2 and MXD1

Number of citations of the paper that reports this interaction (PubMedID 11602341)
65

Data Source:
HPRD (in vitro, in vivo)

		CD2	MXD1
Description		CD2 molecule	MAX dimerization protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Protein-containing Complex Membrane Raft Anchored Component Of Plasma Membrane	Nuclear Chromatin Nucleus Nucleoplasm Mitochondrion Cytosol
	Molecular Function	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Identical Protein Binding Protein Self-association	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Leukocyte Migration Cell-cell Adhesion Positive Regulation Of Interferon-gamma Secretion Positive Regulation Of Interleukin-8 Secretion	Negative Regulation Of Transcription By RNA Polymerase II
Pathways		Cell surface interactions at the vascular wall
Drugs		Alefacept
Diseases
GWAS		Body mass index ( 28552196) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Carotid plaque burden (smoking interaction) ( 24954085) High light scatter reticulocyte count ( 27863252) Mean platelet volume ( 27863252) Platelet count ( 27863252) Red cell distribution width ( 28957414)
Interacting Genes		21 interacting genes: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 DNAJC5 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC SH3KBP1 SP1 UBC	19 interacting genes: AKT1 APP CD2 HDAC1 HDAC2 MAX MLX MOGS MYC MYCL MYCN PML PRAM1 RPS6KA1 RPS6KB1 SAP30 SIN3A SIN3B SMC3
Entrez ID		914	4084
HPRD ID		01750	02487
Ensembl ID		ENSG00000116824	ENSG00000059728
Uniprot IDs		P06729 Q53F96	B7ZLI7 Q05195
PDB IDs		1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I	1E91 1G1E 1NLW 1PD7 1S5Q
Enriched GO Terms of Interacting Partners?
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