MXD1 and MOGS

		MXD1	MOGS
Description		MAX dimerization protein 1	mannosyl-oligosaccharide glucosidase
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Mitochondrion Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Dimerization Activity	Mannosyl-oligosaccharide Glucosidase Activity Glucosidase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II	Protein Folding Protein N-linked Glycosylation Oligosaccharide Metabolic Process
Pathways			Defective MOGS causes MOGS-CDG (CDG-2b) N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type II
GWAS		Carotid plaque burden (smoking interaction) ( 24954085) High light scatter reticulocyte count ( 27863252) Mean platelet volume ( 27863252) Platelet count ( 27863252) Red cell distribution width ( 28957414)
Interacting Genes		19 interacting genes: AKT1 APP CD2 HDAC1 HDAC2 MAX MLX MOGS MYC MYCL MYCN PML PRAM1 RPS6KA1 RPS6KB1 SAP30 SIN3A SIN3B SMC3	9 interacting genes: C1D CHGB ETAA1 EXOC6B MXD1 PCBP1 RAB11FIP5 REL VPS54
Entrez ID		4084	7841
HPRD ID		02487	03214
Ensembl ID		ENSG00000059728	ENSG00000115275
Uniprot IDs		B7ZLI7 Q05195	A0A384MDR6 Q13724 Q58F09
PDB IDs		1E91 1G1E 1NLW 1PD7 1S5Q
Enriched GO Terms of Interacting Partners?
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