CD2 and CD53

Number of citations of the paper that reports this interaction (PubMedID 1346273)
13

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CD2	CD53
Description		CD2 molecule	CD53 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Protein-containing Complex Membrane Raft Anchored Component Of Plasma Membrane	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Identical Protein Binding Protein Self-association	Protein Binding
	Biological Process	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Leukocyte Migration Cell-cell Adhesion Positive Regulation Of Interferon-gamma Secretion Positive Regulation Of Interleukin-8 Secretion	Signal Transduction Neutrophil Degranulation Positive Regulation Of Myoblast Fusion
Pathways		Cell surface interactions at the vascular wall	Neutrophil degranulation
Drugs		Alefacept
Diseases
GWAS		Body mass index ( 28552196) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Cytomegalovirus antibody response ( 21993531) Obesity-related traits ( 23251661)
Interacting Genes		21 interacting genes: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 DNAJC5 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC SH3KBP1 SP1 UBC	6 interacting genes: CD2 CD4 CD9 GGT1 IL2 IL4
Entrez ID		914	963
HPRD ID		01750	01054
Ensembl ID		ENSG00000116824	ENSG00000143119
Uniprot IDs		P06729 Q53F96	B4DQB5 P19397
PDB IDs		1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I
Enriched GO Terms of Interacting Partners?
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