ESCO2 and MCM6

Number of citations of the paper that reports this interaction (PubMedID 30100344)
2

Data Source:
BioGRID (pull down)

		ESCO2	MCM6
Description		establishment of sister chromatid cohesion N-acetyltransferase 2	minichromosome maintenance complex component 6
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin XY Body Nucleoplasm Chromosome Golgi Apparatus Chromocenter Cell Junction Nuclear Pericentric Heterochromatin Site Of Double-strand Break	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm MCM Complex
	Molecular Function	Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Acetyltransferase Activity Metal Ion Binding	DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Identical Protein Binding Single-stranded DNA-dependent ATP-dependent 3'-5' DNA Helicase Activity
	Biological Process	Hematopoietic Progenitor Cell Differentiation Regulation Of DNA Replication Double-strand Break Repair Sister Chromatid Cohesion Post-translational Protein Acetylation Protein Localization To Chromatin	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation Mitotic DNA Replication
Pathways		Establishment of Sister Chromatid Cohesion	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases		ESCO2-related disorders, including: Roberts syndrome; SC phocomelia syndrome
GWAS			Body mass index ( 25673413) Hip circumference ( 25673412) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		8 interacting genes: MCM2 MCM4 MCM5 MCM6 MCM7 MMS22L PCNA SMC3	36 interacting genes: C2CD6 CCNA1 CDC45 CDC7 CDKN2A CDT1 CHEK1 CRLS1 DBF4 ESCO2 FAM161A GMNN HSPB1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MCMBP MLLT3 MTDH NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 UBE3A ZBTB9
Entrez ID		157570	4175
HPRD ID		18564	03485
Ensembl ID		ENSG00000171320	ENSG00000076003
Uniprot IDs		Q56NI9	Q14566
PDB IDs			2KLQ 2LE8
Enriched GO Terms of Interacting Partners?
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