USP2 and TRIM39

Number of citations of the paper that reports this interaction (PubMedID 23105109)
16

Data Source:
BioGRID (two hybrid)

		USP2	TRIM39
Description		ubiquitin specific peptidase 2	tripartite motif containing 39
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Membrane Perinuclear Region Of Cytoplasm	Nucleus Mitochondrion Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cyclin Binding Ubiquitin Protein Ligase Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Identical Protein Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Cell Cycle Muscle Organ Development Protein Deubiquitination Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Locomotor Rhythm Positive Regulation Of Mitotic Cell Cycle Circadian Behavior Protein Stabilization	Apoptotic Process Mitotic G2 DNA Damage Checkpoint Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Stabilization Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Regulation of TP53 Degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Serum uric acid levels ( 30993211) Urate levels ( 31578528 23263486)	Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cutaneous lupus erythematosus ( 25827949) Neuroticism ( 29255261)
Interacting Genes		81 interacting genes: APP AURKA BAP1 BEGAIN BEND5 BRCA1 CBLC CCDC136 CCDC57 CCDC85B CCND1 CRY1 CTNNB1 DTX3 ENPP1 ERBB2 GOLGA2 H2AC20 HOMER3 HOOK1 HOOK2 IHO1 IKBKG IL1RL2 KIFC3 KRT15 KRT40 LHX4 LMNA LNX2 LONRF1 LRSAM1 LZTS2 MALT1 MAP3K2 MDM2 MNAT1 MTUS2 MYC NDEL1 NEFL NFKB2 NOTCH1 ORC3 ORC5 PALB2 PCGF6 PCNA PEX5 PIK3R3 PLA2G2A PNMA1 RAD18 RBCK1 RNF125 RNF126 RNF144B RNF166 SNCA TRAF2 TRAF6 TRAIP TRIM21 TRIM23 TRIM27 TRIM34 TRIM35 TRIM39 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 TRIM8 TRIM9 UBE2S UBOX5 USP21 VCAM1 VPS52 ZAP70	55 interacting genes: APP CACTIN CCNC DCUN1D1 DCX DIP2A EIF4A2 EPHB6 HINFP KDM1A LMNA LNX1 LXN MED18 MNAT1 OTUB2 OTUD6A PDLIM5 PLCD4 POLI PRPF3 PSMA6 PSMD9 RECK RNF166 SMCO3 TP53 TRIM17 TRIM21 TRIM8 TTC32 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBTD1 UBTD2 UBXN1 UBXN6 USP2 USP39 USP5 WDFY3 ZKSCAN4 ZNF26
Entrez ID		9099	56658
HPRD ID		05287	09298
Ensembl ID		ENSG00000036672	ENSG00000204599
Uniprot IDs		O75604	A0A024RCP5 A0A024RCR1 Q9HCM9
PDB IDs		2HD5 2IBI 3NHE 3V6C 3V6E 5XU8 5XVE 6DGF	2DID 2DIF 2ECJ
Enriched GO Terms of Interacting Partners?
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