USP2 and ENPP1

Number of citations of the paper that reports this interaction (PubMedID 27226596)
3

Data Source:
BioGRID (enzymatic study)

		USP2	ENPP1
Description		ubiquitin specific peptidase 2	ectonucleotide pyrophosphatase/phosphodiesterase 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Membrane Perinuclear Region Of Cytoplasm	Extracellular Space Cell Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cyclin Binding Ubiquitin Protein Ligase Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Identical Protein Binding Metal Ion Binding	Nucleic Acid Binding Exonuclease Activity Phosphodiesterase I Activity Nucleotide Diphosphatase Activity Scavenger Receptor Activity Insulin Receptor Binding Calcium Ion Binding Protein Binding ATP Binding Zinc Ion Binding Polysaccharide Binding NADH Pyrophosphatase Activity Protein Homodimerization Activity Nucleoside-triphosphate Diphosphatase Activity 3'-phosphoadenosine 5'-phosphosulfate Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Cell Cycle Muscle Organ Development Protein Deubiquitination Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Locomotor Rhythm Positive Regulation Of Mitotic Cell Cycle Circadian Behavior Protein Stabilization	Generation Of Precursor Metabolites And Energy Riboflavin Metabolic Process Phosphate-containing Compound Metabolic Process Endocytosis Immune Response Nucleoside Triphosphate Catabolic Process Negative Regulation Of Cell Growth Melanocyte Differentiation Regulation Of Bone Mineralization Negative Regulation Of Bone Mineralization Inorganic Diphosphate Transport Cellular Phosphate Ion Homeostasis Sequestering Of Triglyceride Biomineral Tissue Development Negative Regulation Of Protein Autophosphorylation Cellular Response To Insulin Stimulus Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Glycogen Biosynthetic Process ATP Metabolic Process Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Negative Regulation Of Hh Target Transcription Factor Activity
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Regulation of TP53 Degradation	Vitamin B2 (riboflavin) metabolism Vitamin B5 (pantothenate) metabolism
Drugs			Ribavirin Amifostine
Diseases			Ossification of the posterior longitudinal ligament of spine (OPLL) Type II diabetes mellitus Generalized arterial calcification of infancy
GWAS		Serum uric acid levels ( 30993211) Urate levels ( 31578528 23263486)	Height ( 28552196) Obesity-related traits ( 23251661)
Interacting Genes		81 interacting genes: APP AURKA BAP1 BEGAIN BEND5 BRCA1 CBLC CCDC136 CCDC57 CCDC85B CCND1 CRY1 CTNNB1 DTX3 ENPP1 ERBB2 GOLGA2 H2AC20 HOMER3 HOOK1 HOOK2 IHO1 IKBKG IL1RL2 KIFC3 KRT15 KRT40 LHX4 LMNA LNX2 LONRF1 LRSAM1 LZTS2 MALT1 MAP3K2 MDM2 MNAT1 MTUS2 MYC NDEL1 NEFL NFKB2 NOTCH1 ORC3 ORC5 PALB2 PCGF6 PCNA PEX5 PIK3R3 PLA2G2A PNMA1 RAD18 RBCK1 RNF125 RNF126 RNF144B RNF166 SNCA TRAF2 TRAF6 TRAIP TRIM21 TRIM23 TRIM27 TRIM34 TRIM35 TRIM39 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 TRIM8 TRIM9 UBE2S UBOX5 USP21 VCAM1 VPS52 ZAP70	2 interacting genes: INSR USP2
Entrez ID		9099	5167
HPRD ID		05287	01415
Ensembl ID		ENSG00000036672	ENSG00000197594
Uniprot IDs		O75604	P22413
PDB IDs		2HD5 2IBI 3NHE 3V6C 3V6E 5XU8 5XVE 6DGF	2YS0
Enriched GO Terms of Interacting Partners?
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