USP2 and ORC5

Number of citations of the paper that reports this interaction (PubMedID 31160578)
1

Data Source:
BioGRID (enzymatic study)

		USP2	ORC5
Description		ubiquitin specific peptidase 2	origin recognition complex subunit 5
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Membrane Perinuclear Region Of Cytoplasm	Nuclear Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cyclin Binding Ubiquitin Protein Ligase Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Identical Protein Binding Metal Ion Binding	Nucleotide Binding Molecular_function DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Cell Cycle Muscle Organ Development Protein Deubiquitination Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Locomotor Rhythm Positive Regulation Of Mitotic Cell Cycle Circadian Behavior Protein Stabilization	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Regulation Of DNA Replication
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Regulation of TP53 Degradation	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Serum uric acid levels ( 30993211) Urate levels ( 31578528 23263486)	Alcohol consumption (drinks per week) ( 30643258) Night sleep phenotypes ( 27126917) Sucrose liking ( 31005972)
Interacting Genes		81 interacting genes: APP AURKA BAP1 BEGAIN BEND5 BRCA1 CBLC CCDC136 CCDC57 CCDC85B CCND1 CRY1 CTNNB1 DTX3 ENPP1 ERBB2 GOLGA2 H2AC20 HOMER3 HOOK1 HOOK2 IHO1 IKBKG IL1RL2 KIFC3 KRT15 KRT40 LHX4 LMNA LNX2 LONRF1 LRSAM1 LZTS2 MALT1 MAP3K2 MDM2 MNAT1 MTUS2 MYC NDEL1 NEFL NFKB2 NOTCH1 ORC3 ORC5 PALB2 PCGF6 PCNA PEX5 PIK3R3 PLA2G2A PNMA1 RAD18 RBCK1 RNF125 RNF126 RNF144B RNF166 SNCA TRAF2 TRAF6 TRAIP TRIM21 TRIM23 TRIM27 TRIM34 TRIM35 TRIM39 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 TRIM8 TRIM9 UBE2S UBOX5 USP21 VCAM1 VPS52 ZAP70	30 interacting genes: CALCOCO2 CDC45 CDC5L CDC6 CDC7 DBF4 DMRTA1 H3-4 H4-16 KRT18 LAMB2 MCM2 MCM3 MCM4 MCM5 MCM7 NIF3L1 NONO ORC1 ORC2 ORC3 ORC4 ORC6 RPA2 SIPA1L2 STAB1 TAX1BP1 TXNDC11 UBQLN4 USP2
Entrez ID		9099	5001
HPRD ID		05287	09086
Ensembl ID		ENSG00000036672	ENSG00000164815
Uniprot IDs		O75604	A4D0P7 O43913 Q53FC8
PDB IDs		2HD5 2IBI 3NHE 3V6C 3V6E 5XU8 5XVE 6DGF	5UJ7 5UJM
Enriched GO Terms of Interacting Partners?
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