ORC5 and SIPA1L2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ORC5	SIPA1L2
Description		origin recognition complex subunit 5	signal induced proliferation associated 1 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol	Cellular_component
	Molecular Function	Nucleotide Binding Molecular_function DNA Replication Origin Binding Protein Binding ATP Binding	GTPase Activator Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Regulation Of DNA Replication	Biological_process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Night sleep phenotypes ( 27126917) Sucrose liking ( 31005972)	Immunoglobulin A ( 20694011) Parkinson's disease ( 25064009 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Post-traumatic stress disorder ( 24677629) Reduced foot dorsiflexion strength in Charcot-Marie-Tooth disease type 1A ( 30706531) Schizophrenia ( 30285260) Smooth-surface caries ( 24556642)
Interacting Genes		30 interacting genes: CALCOCO2 CDC45 CDC5L CDC6 CDC7 DBF4 DMRTA1 H3-4 H4-16 KRT18 LAMB2 MCM2 MCM3 MCM4 MCM5 MCM7 NIF3L1 NONO ORC1 ORC2 ORC3 ORC4 ORC6 RPA2 SIPA1L2 STAB1 TAX1BP1 TXNDC11 UBQLN4 USP2	4 interacting genes: AP3M1 DDX6 ORC5 TGM2
Entrez ID		5001	57568
HPRD ID		09086	15346
Ensembl ID		ENSG00000164815	ENSG00000116991
Uniprot IDs		A4D0P7 O43913 Q53FC8	Q9P2F8
PDB IDs		5UJ7 5UJM
Enriched GO Terms of Interacting Partners?
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