KMT2D and ASH2L

Number of citations of the paper that reports this interaction (PubMedID 16603732)
72

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		KMT2D	ASH2L
Description		lysine methyltransferase 2D	ASH2 like, histone lysine methyltransferase complex subunit
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex	Nucleus Nucleoplasm Nuclear Euchromatin Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Transcription Coactivator Activity Protein Binding Histone Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding Metal Ion Binding	Protein Binding Beta-catenin Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding Metal Ion Binding Euchromatin Binding
	Biological Process	Oocyte Growth Chromatin Silencing Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Estrogen Histone H3-K4 Dimethylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Oogenesis Histone H3-K4 Methylation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation Beta-catenin-TCF Complex Assembly	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Proliferation Hemopoiesis Response To Estrogen Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Methylation Beta-catenin-TCF Complex Assembly
Pathways		Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases		Kabuki syndrome
GWAS		Chronotype ( 30696823) General cognitive ability ( 29844566) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435)	Menopause (age at onset) ( 22267201) Schizophrenia ( 29483656)
Interacting Genes		9 interacting genes: AKT1 ASH2L CTNNB1 ESR1 H3C14 MEN1 POLR2A SMAD1 SMAD9	25 interacting genes: BARD1 BRCA1 CHD8 CTNNB1 DNMT3L DPY30 EP300 H3-4 H3C1 KMT2A KMT2B KMT2D KMT2E MEN1 PPP1CC PRMT1 RBBP5 SMAD9 SMURF1 SMURF2 TGFBR1 TP53 UNC119 WWP1 ZSCAN1
Entrez ID		8085	9070
HPRD ID		03664	05309
Ensembl ID		ENSG00000167548	ENSG00000129691
Uniprot IDs		O14686 Q59FG6 Q6PIA1	B4DPT1 F5H8F7 Q9UBL3
PDB IDs		3UVK 4ERQ 4Z4P 6O7G	3RSN 3S32 3TOJ 4RIQ 4X8N 4X8P 5F6K 5F6L 6E2H 6KIU 6KIV 6KIW 6KIX 6KIZ
Enriched GO Terms of Interacting Partners?
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