RBBP5 and H3C14

Number of citations of the paper that reports this interaction (PubMedID 12482968)
103

Data Source:
BioGRID (pull down)

		RBBP5	H3C14
Description		RB binding protein 5, histone lysine methyltransferase complex subunit	H3 clustered histone 14
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Exosome
	Molecular Function	Protein Binding Methylated Histone Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Cellular Response To DNA Damage Stimulus Response To Estrogen Post-translational Protein Modification Regulation Of Megakaryocyte Differentiation Histone H3-K4 Methylation Beta-catenin-TCF Complex Assembly	Chromatin Silencing At RDNA Chromatin Organization Nucleosome Assembly Blood Coagulation Interleukin-7-mediated Signaling Pathway Cellular Protein Metabolic Process Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Silencing By MiRNA
Pathways		Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Neddylation	Interleukin-7 signaling Interleukin-7 signaling Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Chromatin modifying enzymes SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Amyloid fiber formation Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 28240269) Mean platelet volume ( 24026423)
Interacting Genes		11 interacting genes: ASH2L CHD8 CTBP1 CTNNB1 H3-4 H3C14 KMT2A KMT2B MEN1 RB1 UBE2I	61 interacting genes: ARID4A ATRX AURKB BIRC5 BRD1 BRD4 BRD7 BRPF1 CDCA8 CDK8 CHUK DDB2 DNMT3L EHMT2 ELP3 EP300 HDGFL2 INCENP ING1 JADE1 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3A KDM4C KDM6A KMT2A KMT2B KMT2C KMT2D MSL2 NAP1L4 NASP NCOA6 NRDC NSD2 PHF21A PIM1 PKN1 PRMT6 PTMA PWWP3A RBBP4 RBBP5 RERE RNF20 RNF4 RPS6KA5 SETD1A SETD1B SETD7 SMARCA4 SMYD2 STAT6 TARS2 TBL1X UHRF1 VRK1
Entrez ID		5929	126961
HPRD ID		02826	11822
Ensembl ID		ENSG00000117222	ENSG00000203811
Uniprot IDs		A0A024R9B5 B4DLF8 Q15291	Q71DI3
PDB IDs		3P4F 4X8N 4X8P 5F6K 5F6L 6KIU 6KIV 6KIW 6KIX 6KIZ 6KM7	2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93 4MZF 4MZG 4MZH 4OUC 5B0Y 5B0Z 5B40 5BO0 5CIU 5VAC 6ACE 6FML
Enriched GO Terms of Interacting Partners?
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