TOP3B and CHD8

Number of citations of the paper that reports this interaction (PubMedID 11549288)
3

Data Source:
HPRD (two hybrid)

		TOP3B	CHD8
Description		DNA topoisomerase III beta	chromodomain helicase DNA binding protein 8
Image
GO Annotations	Cellular Component	Condensed Chromosome Nucleus	Nucleus Nucleoplasm Plasma Membrane Protein-containing Complex MLL1 Complex
	Molecular Function	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I Activity Protein Binding	P53 Binding DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Beta-catenin Binding DNA-dependent ATPase Activity Methylated Histone Binding Histone Binding Armadillo Repeat Domain Binding
	Biological Process	DNA Topological Change Chromosome Segregation	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Brain Development Wnt Signaling Pathway DNA Duplex Unwinding Social Behavior ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Digestive Tract Development Prepulse Inhibition Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process
Pathways			Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Attention function in attention deficit hyperactive disorder ( 26174813) Bipolar disorder ( 31043756) Diastolic blood pressure ( 29208002) Response to selective serotonin reuptake inhibitors in depression ( 27622933)	Height ( 31562340)
Interacting Genes		18 interacting genes: ADAMTSL4 C1QBP CENPF CHD8 CHIC2 FBLN5 GRN KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TRIM41 UPF2 ZFPM1 ZNF408	10 interacting genes: AR ASH2L CHD7 CREB1 CTCF CTNNB1 RBBP5 RCHY1 TOP3B WDR5
Entrez ID		8940	57680
HPRD ID		04662	16712
Ensembl ID		ENSG00000100038	ENSG00000100888
Uniprot IDs		A0A024R1C2 A8K4N2 O95985	Q9HCK8
PDB IDs		5GVC 5GVE	2CKA 2DL6
Enriched GO Terms of Interacting Partners?
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