TOP3B and CENPF

Number of citations of the paper that reports this interaction (PubMedID 11549288)
3

Data Source:
HPRD (two hybrid)

		TOP3B	CENPF
Description		DNA topoisomerase III beta	centromere protein F
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Nucleus	Chromosome, Centromeric Region Kinetochore Chromatin Spindle Pole Condensed Chromosome Outer Kinetochore Cell Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Axoneme Nuclear Matrix Midbody Ciliary Basal Body Pronucleus Perinuclear Region Of Cytoplasm Ciliary Transition Fiber
	Molecular Function	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I Activity Protein Binding	Chromatin Binding Protein Binding Protein C-terminus Binding Transcription Factor Binding Protein Homodimerization Activity Dynein Complex Binding
	Biological Process	DNA Topological Change Chromosome Segregation	Mitotic Cell Cycle Kidney Development Chromosome Segregation Mitotic Spindle Assembly Checkpoint Muscle Organ Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Regulation Of Striated Muscle Tissue Development Ventricular System Development Cell Differentiation Response To Drug Negative Regulation Of Transcription, DNA-templated Cell Division Metaphase Plate Congression Kinetochore Assembly Regulation Of Cell Cycle DNA Biosynthetic Process
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Polo-like kinase mediated events Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Attention function in attention deficit hyperactive disorder ( 26174813) Bipolar disorder ( 31043756) Diastolic blood pressure ( 29208002) Response to selective serotonin reuptake inhibitors in depression ( 27622933)	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Lung function (FVC) ( 30061609) Response to antineoplastic agents ( 21659360)
Interacting Genes		18 interacting genes: ADAMTSL4 C1QBP CENPF CHD8 CHIC2 FBLN5 GRN KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TRIM41 UPF2 ZFPM1 ZNF408	16 interacting genes: BRAP CENPE CHMP2B FNTA FNTB HSD11B1 IRF6 KLHL41 NDEL1 NUP133 PLOD2 SLC30A1 SLC4A1AP SNAP25 SVIL TOP3B
Entrez ID		8940	1063
HPRD ID		04662	02582
Ensembl ID		ENSG00000100038	ENSG00000117724
Uniprot IDs		A0A024R1C2 A8K4N2 O95985	P49454
PDB IDs		5GVC 5GVE
Enriched GO Terms of Interacting Partners?
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