SKAP2 and FYB1

Number of citations of the paper that reports this interaction (PubMedID 9671755)
47

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SKAP2	FYB1
Description		src kinase associated phosphoprotein 2	FYN binding protein 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Nucleus Cytosol Plasma Membrane Actin Cytoskeleton Cell Junction Protein-containing Complex
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Signaling Receptor Binding Protein Binding Lipid Binding Protein-containing Complex Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction B Cell Activation Protein-containing Complex Assembly	Immune Response Integrin-mediated Signaling Pathway Biological_process T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane
Pathways		Signal regulatory protein family interactions	Generation of second messenger molecules Generation of second messenger molecules Signal regulatory protein family interactions
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic venous disease ( 28374850) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Peak expiratory flow ( 30804560) Small cell lung carcinoma ( 28604730) Systemic lupus erythematosus ( 28714469)
Interacting Genes		19 interacting genes: APP BLK FAM102A FASLG FGR FRK FYB1 FYN HCK KHDRBS1 LCK LYN NCK2 PRAM1 PTK2B SRC SRMS TGFBR1 YES1	15 interacting genes: BCAR1 CBL CBLB ENAH EVL FASLG FYN LCP2 NCK2 SH2D1A SKAP1 SKAP2 SRC VASP WAS
Entrez ID		8935	2533
HPRD ID		05558	04107
Ensembl ID		ENSG00000005020	ENSG00000082074
Uniprot IDs		B7Z5R3 O75563	O15117
PDB IDs		3OMH	1RI9 2GTJ 2GTO
Enriched GO Terms of Interacting Partners?
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