SKAP2 and FRK

Number of citations of the paper that reports this interaction (PubMedID 29568343)
1

Data Source:
BioGRID (protein complementation assay)

		SKAP2	FRK
Description		src kinase associated phosphoprotein 2	fyn related Src family tyrosine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Extracellular Region Intracellular Nucleus Nucleoplasm Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction B Cell Activation Protein-containing Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Proliferation Cell Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Neutrophil Degranulation
Pathways		Signal regulatory protein family interactions	Neutrophil degranulation Regulation of PTEN stability and activity
Drugs			Dasatinib Regorafenib
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic venous disease ( 28374850) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Peak expiratory flow ( 30804560) Small cell lung carcinoma ( 28604730) Systemic lupus erythematosus ( 28714469)	Age-related macular degeneration ( 21665990) Appendicular lean mass ( 28724990) C-reactive protein levels ( 30388399) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 20686565) Choroid plexus volume ( 31530798) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Diastolic blood pressure ( 27841878) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) HDL cholesterol levels ( 30698716) LDL cholesterol ( 24097068 20686565) LDL cholesterol levels ( 28334899) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Longevity ( 30294719) Photic sneeze reflex ( 27182965) Total cholesterol levels ( 28334899) Urate levels ( 23263486)
Interacting Genes		19 interacting genes: APP BLK FAM102A FASLG FGR FRK FYB1 FYN HCK KHDRBS1 LCK LYN NCK2 PRAM1 PTK2B SRC SRMS TGFBR1 YES1	6 interacting genes: BNIP2 EGFR KHDRBS1 RB1 SF3B4 SKAP2
Entrez ID		8935	2444
HPRD ID		05558	05954
Ensembl ID		ENSG00000005020	ENSG00000111816
Uniprot IDs		B7Z5R3 O75563	P42685
PDB IDs		3OMH
Enriched GO Terms of Interacting Partners?
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