FRK and BNIP2

Number of citations of the paper that reports this interaction (PubMedID 21516116)
94

Data Source:
BioGRID (two hybrid)

		FRK	BNIP2
Description		fyn related Src family tyrosine kinase	BCL2 interacting protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Intracellular Nucleus Nucleoplasm Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome	Nuclear Envelope Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding	Exopolyphosphatase Activity GTPase Activator Activity Calcium Ion Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Proliferation Cell Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Neutrophil Degranulation	Polyphosphate Catabolic Process Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Muscle Cell Differentiation
Pathways		Neutrophil degranulation Regulation of PTEN stability and activity	Myogenesis Myogenesis
Drugs		Dasatinib Regorafenib
Diseases
GWAS		Age-related macular degeneration ( 21665990) Appendicular lean mass ( 28724990) C-reactive protein levels ( 30388399) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 20686565) Choroid plexus volume ( 31530798) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Diastolic blood pressure ( 27841878) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) HDL cholesterol levels ( 30698716) LDL cholesterol ( 24097068 20686565) LDL cholesterol levels ( 28334899) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Longevity ( 30294719) Photic sneeze reflex ( 27182965) Total cholesterol levels ( 28334899) Urate levels ( 23263486)	Gut microbiota (bacterial taxa) ( 27723756)
Interacting Genes		6 interacting genes: BNIP2 EGFR KHDRBS1 RB1 SF3B4 SKAP2	14 interacting genes: ARHGAP1 ARHGAP8 BCL2 BNIPL CDC42 CREB3 FATE1 FGFR1 FRK KLC1 LMNA MYO5B NCBP1 UPK1B
Entrez ID		2444	663
HPRD ID		05954	04481
Ensembl ID		ENSG00000111816	ENSG00000140299
Uniprot IDs		P42685	J3KN59 Q12982
PDB IDs
Enriched GO Terms of Interacting Partners?
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