MBD2 and MBD3

Number of citations of the paper that reports this interaction (PubMedID 10947852)
42

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		MBD2	MBD3
Description		methyl-CpG binding domain protein 2	methyl-CpG binding domain protein 3
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytosol Protein-containing Complex	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Satellite DNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Protein Domain Specific Binding Nucleosomal DNA Binding SiRNA Binding C2H2 Zinc Finger Domain Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing At RDNA Methylation-dependent Chromatin Silencing Heart Development Aging Response To Mechanical Stimulus Positive Regulation Of Wnt Signaling Pathway Response To Nutrient Levels Response To Estradiol Cellular Protein-containing Complex Assembly Positive Regulation Of Chromatin Binding Regulation Of Cell Proliferation Maternal Behavior ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Negative Regulation Of Transcription, DNA-templated Embryonic Organ Development Cellular Response To Organic Cyclic Compound	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Methylation-dependent Chromatin Silencing Brain Development Heart Development Aging Tissue Development Histone Acetylation Response To Nutrient Levels Response To Estradiol ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Embryonic Organ Development Regulation Of Signal Transduction By P53 Class Mediator
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Nickel levels ( 26025379) Periodontitis (Mean PAL) ( 24024966) Prostate cancer ( 29892016) Psoriasis ( 23143594)
Interacting Genes		15 interacting genes: CREBBP DHX9 GATAD2A GATAD2B GPN1 HDAC1 HDAC2 HINFP LAMTOR3 MBD3 MBD3L1 MBD3L2 RBBP4 SIN3A TBP	29 interacting genes: ATF7 AURKA BCL11B CEP76 GATAD2A GATAD2B GOLGA2 H3-4 HDAC1 ICA1 JUN KDM1A KDM5B KRT15 MBD2 MBD3L1 MBD3L2 MECOM MTA2 RBBP4 RBBP7 RCN3 SDCBP SMARCA4 SPEN TET1 TRIM54 ZBTB7A ZNF277
Entrez ID		8932	53615
HPRD ID		04647	04653
Ensembl ID		ENSG00000134046	ENSG00000071655
Uniprot IDs		A0A024R2B8 Q9UBB5	O95983
PDB IDs		2L2L 6C1A 6C1T 6C1U 6C1V 6C2F 6CNP 6CNQ	2MB7 6CC8 6CCG 6CEU 6CEV
Enriched GO Terms of Interacting Partners?
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