MBD3 and RBBP7

Number of citations of the paper that reports this interaction (PubMedID 10444591)
356

Data Source:
HPRD (in vivo, in vitro)

		MBD3	RBBP7
Description		methyl-CpG binding domain protein 3	RB binding protein 7, chromatin remodeling factor
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GO Annotations	Cellular Component	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex	Nucleus Nucleoplasm Cytosol NuRD Complex ESC/E(Z) Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Methylation-dependent Chromatin Silencing Brain Development Heart Development Aging Tissue Development Histone Acetylation Response To Nutrient Levels Response To Estradiol ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Embryonic Organ Development Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Negative Regulation Of Cell Growth CENP-A Containing Nucleosome Assembly Post-translational Protein Modification Negative Regulation Of Gene Expression, Epigenetic Response To Steroid Hormone Negative Regulation Of G0 To G1 Transition Cellular Heat Acclimation Regulation Of Signal Transduction By P53 Class Mediator
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription	PRC2 methylates histones and DNA Oxidative Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HATs acetylate histones RMTs methylate histone arginines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis Deposition of new CENPA-containing nucleosomes at the centromere Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Neddylation Transcriptional Regulation by E2F6 HCMV Early Events
Drugs
Diseases
GWAS
Interacting Genes		29 interacting genes: ATF7 AURKA BCL11B CEP76 GATAD2A GATAD2B GOLGA2 H3-4 HDAC1 ICA1 JUN KDM1A KDM5B KRT15 MBD2 MBD3L1 MBD3L2 MECOM MTA2 RBBP4 RBBP7 RCN3 SDCBP SMARCA4 SPEN TET1 TRIM54 ZBTB7A ZNF277	33 interacting genes: APPL1 APPL2 BCL11A BCL11B BRCA1 BRMS1 BRMS1L CREBBP CYTOR DDB1 DHX30 ESR1 FOXK2 H3-4 H3C1 HDAC1 HDAC2 HUWE1 ING1 MBD3 MBD3L2 MTA2 NR2E3 PRKAA2 RB1 RBBP4 RBP1 SALL2 SAP30 SIN3A SUMO2 SUV39H1 TWIST1
Entrez ID		53615	5931
HPRD ID		04653	04231
Ensembl ID		ENSG00000071655	ENSG00000102054
Uniprot IDs		O95983	Q16576 Q6FHQ0
PDB IDs		2MB7 6CC8 6CCG 6CEU 6CEV	3CFS 3CFV
Enriched GO Terms of Interacting Partners?
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