MBD3 and MTA2

Number of citations of the paper that reports this interaction (PubMedID 26344197)
117

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		MBD3	MTA2
Description		methyl-CpG binding domain protein 3	metastasis associated 1 family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex	Histone Deacetylase Complex Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Membrane NuRD Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Activity Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Methylation-dependent Chromatin Silencing Brain Development Heart Development Aging Tissue Development Histone Acetylation Response To Nutrient Levels Response To Estradiol ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Embryonic Organ Development Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Assembly Or Disassembly Regulation Of Fibroblast Migration Histone Deacetylation ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Signal Transduction By P53 Class Mediator
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS			Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		29 interacting genes: ATF7 AURKA BCL11B CEP76 GATAD2A GATAD2B GOLGA2 H3-4 HDAC1 ICA1 JUN KDM1A KDM5B KRT15 MBD2 MBD3L1 MBD3L2 MECOM MTA2 RBBP4 RBBP7 RCN3 SDCBP SMARCA4 SPEN TET1 TRIM54 ZBTB7A ZNF277	22 interacting genes: APPL1 APPL2 BCL11B ESR1 FKBP3 H3-4 HDAC2 HNRNPD MBD3 MBD3L2 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN SUMO2 TP53 TSC22D3 UBE3C YY1
Entrez ID		53615	9219
HPRD ID		04653	07233
Ensembl ID		ENSG00000071655	ENSG00000149480
Uniprot IDs		O95983	A0A024R534 O94776
PDB IDs		2MB7 6CC8 6CCG 6CEU 6CEV
Enriched GO Terms of Interacting Partners?
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