MBD2 and GATAD2A

Number of citations of the paper that reports this interaction (PubMedID 12183469)
34

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		MBD2	GATAD2A
Description		methyl-CpG binding domain protein 2	GATA zinc finger domain containing 2A
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytosol Protein-containing Complex	Nucleus Nucleoplasm NuRD Complex Nuclear Speck
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Satellite DNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Protein Domain Specific Binding Nucleosomal DNA Binding SiRNA Binding C2H2 Zinc Finger Domain Binding	Protein Binding Zinc Ion Binding Protein Binding, Bridging Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing At RDNA Methylation-dependent Chromatin Silencing Heart Development Aging Response To Mechanical Stimulus Positive Regulation Of Wnt Signaling Pathway Response To Nutrient Levels Response To Estradiol Cellular Protein-containing Complex Assembly Positive Regulation Of Chromatin Binding Regulation Of Cell Proliferation Maternal Behavior ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Negative Regulation Of Transcription, DNA-templated Embryonic Organ Development Cellular Response To Organic Cyclic Compound	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Negative Regulation Of Transcription, DNA-templated
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Nickel levels ( 26025379) Periodontitis (Mean PAL) ( 24024966) Prostate cancer ( 29892016) Psoriasis ( 23143594)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer ( 29059683) Height ( 25282103 31562340) Nonalcoholic fatty liver disease ( 29385134) Pulse pressure ( 30578418) Red cell distribution width ( 28957414) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Schizophrenia ( 25056061 29483656 23974872) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Strenuous sports or other exercises ( 29899525) Type 2 diabetes ( 28869590)
Interacting Genes		15 interacting genes: CREBBP DHX9 GATAD2A GATAD2B GPN1 HDAC1 HDAC2 HINFP LAMTOR3 MBD3 MBD3L1 MBD3L2 RBBP4 SIN3A TBP	11 interacting genes: CREBBP H2AC20 H2BC21 H3C1 H4C1 KAT2B KRT40 MBD2 MBD3 PAK4 SPOP
Entrez ID		8932	54815
HPRD ID		04647	11741
Ensembl ID		ENSG00000134046	ENSG00000167491
Uniprot IDs		A0A024R2B8 Q9UBB5	A0A024R7K7 A0A024R7M6 Q86YP4
PDB IDs		2L2L 6C1A 6C1T 6C1U 6C1V 6C2F 6CNP 6CNQ	2L2L
Enriched GO Terms of Interacting Partners?
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