ACTN3 and ABI3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ACTN3	ABI3
Description		actinin alpha 3 (gene/pseudogene)	ABI family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Actin Filament Focal Adhesion Pseudopodium Extracellular Exosome	Cytoplasm Membrane Lamellipodium
	Molecular Function	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Ion Channel Binding	Protein Binding SH3 Domain Binding Identical Protein Binding
	Biological Process	Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Muscle Filament Sliding Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate	Peptidyl-tyrosine Phosphorylation Regulation Of Cell Migration
Pathways		Nephrin family interactions Striated Muscle Contraction
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Frontotemporal dementia with GRN mutation ( 29724592)	Alzheimer's disease (late onset) ( 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 31619474) Family history of Alzheimer's disease ( 30617256) Prostate cancer ( 23535732)
Interacting Genes		17 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A BRCA1 C1orf94 KCTD6 MYPN NEBL NRAP PLEKHG2 REL RNF111 SUMO1P1 TRAF1 TRAF2	36 interacting genes: ABI3BP ACTN3 ARMC7 CEP170P1 CEP44 CYFIP2 DTNB DTNBP1 EIF3H ENAH EVL FARSA FBF1 GRB2 HOMER1 HOMER3 KANK2 KIAA0408 KLC3 KLC4 KRT13 KRT15 MAGEA12 MRFAP1L1 NCK2 NUP58 PAK1 PAK2 PSMA1 RUNX1T1 SNAP23 SOS1 TMEM147 VASP WAS WASF2
Entrez ID		89	51225
HPRD ID		02148	05900
Ensembl ID		ENSG00000248746	ENSG00000108798
Uniprot IDs		A0A087WSZ2 B4DZQ2 Q08043	Q9P2A4
PDB IDs		1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?
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