SQSTM1 and TRIB3

Number of citations of the paper that reports this interaction (PubMedID 26268733)
39

Data Source:
BioGRID (pull down, unspecified method)

		SQSTM1	TRIB3
Description		sequestosome 1	tribbles pseudokinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site P-body Nucleoplasm Cytoplasm Mitochondrion Late Endosome Autophagosome Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Sarcomere Intracellular Membrane-bounded Organelle Amphisome Autolysosome Extracellular Exosome Sperm Midpiece Lewy Body	Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding SH2 Domain Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Transcription Corepressor Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Autophagy Of Mitochondrion Mitophagy Positive Regulation Of Protein Phosphorylation Immune System Process Response To Ischemia Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Apoptotic Process Mitochondrion Organization Endosome Organization Protein Localization Regulation Of Mitochondrion Organization Endosomal Transport Macroautophagy Cell Differentiation Negative Regulation Of Protein Ubiquitination Intracellular Signal Transduction Aggrephagy Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Regulation Of Protein Complex Stability Selective Autophagy Interleukin-1-mediated Signaling Pathway Response To Mitochondrial Depolarisation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Perinuclear Region Of Cytoplasm	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Regulation Of Autophagy Regulation Of Glucose Transmembrane Transport Regulation Of Lipid Metabolic Process Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Regulation Of MAP Kinase Activity Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Kinase B Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Pathways		NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival Pink/Parkin Mediated Mitophagy Interleukin-1 signaling Pexophagy	PIP3 activates AKT signaling Activation of AKT2 PPARA activates gene expression Negative regulation of the PI3K/AKT network CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases		Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS		Alzheimer's disease (late onset) ( 24162737)	Information processing speed ( 21130836) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321)
Interacting Genes		98 interacting genes: ATXN3 BCL2 BMPR1B BPTF BRCA1 CALCR CALM1 CAMK2A CCNB1 CDC6 CDK1 CRBN CRYAB CSNK1A1 CSNK2A1 DAZAP2 DNAI1 DNAI2 DNAJC10 EEF1D FKBP4 GABARAP GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 HSPB1 IRAK1 ISG15 KCNAB2 LCK LRRK2 MALT1 MAP1LC3B MAP1LC3C MAP2K5 MAPK13 MAPK14 MAPT MBP MEIS2 MLH1 MTDH NBR1 NCOR1 NR2F2 NTRK1 NTRK2 NTRK3 OPTN PADI1 PAWR PIK3CA PIK3R1 PPHLN1 PRKCD PRKCI PRKCZ RAD23A RAD54L2 RELN RIPK1 RNF166 RNF168 RPL37 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TBK1 TGFBR1 TKT TOE1 TP53INP1 TRAF6 TRIB3 TRIM21 TRIM55 TRIM63 TTN UBA52 UBB UBC UBE2D2 UBE2D3 ULK2 VANGL2 WDR81 XIAP YWHAZ	28 interacting genes: AKT1 AKT2 APOBEC3A APOBEC3C APP ATF4 BMPR2 COPS6 DDIT3 EEF1G FBXO7 GDF9 GIT1 HLA-B KAT5 MDFI PML PRMT5 PSMA3 RARA RBM4 RBM48 RELA RIDA RPGRIP1 RPSA SETDB1 SQSTM1
Entrez ID		8878	57761
HPRD ID		03319	09836
Ensembl ID		ENSG00000161011	ENSG00000101255
Uniprot IDs		Q13501	B4DMM9 J3KR25 Q96RU7
PDB IDs		1Q02 2JY7 2JY8 2K0B 2KNV 4MJS 4UF8 4UF9 5YP7 5YP8 5YPA 5YPB 5YPC 5YPE 5YPF 5YPG 5YPH 6MJ7
Enriched GO Terms of Interacting Partners?
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