TRIB3 and APOBEC3C

Number of citations of the paper that reports this interaction (PubMedID 22977230)
31

Data Source:
BioGRID (pull down, two hybrid)

		TRIB3	APOBEC3C
Description		tribbles pseudokinase 3	apolipoprotein B mRNA editing enzyme catalytic subunit 3C
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane	P-body Nucleus Cytoplasm
	Molecular Function	Transcription Corepressor Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity	RNA Binding Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Deoxycytidine Deaminase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Regulation Of Autophagy Regulation Of Glucose Transmembrane Transport Regulation Of Lipid Metabolic Process Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Regulation Of MAP Kinase Activity Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Kinase B Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress	Cytidine Deamination Negative Regulation Of Transposition Viral Process Cytidine To Uridine Editing Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Defense Response To Virus DNA Cytosine Deamination DNA Demethylation
Pathways		PIP3 activates AKT signaling Activation of AKT2 PPARA activates gene expression Negative regulation of the PI3K/AKT network CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	mRNA Editing: C to U Conversion Formation of the Editosome
Drugs
Diseases
GWAS		Information processing speed ( 21130836) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321)	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)
Interacting Genes		28 interacting genes: AKT1 AKT2 APOBEC3A APOBEC3C APP ATF4 BMPR2 COPS6 DDIT3 EEF1G FBXO7 GDF9 GIT1 HLA-B KAT5 MDFI PML PRMT5 PSMA3 RARA RBM4 RBM48 RELA RIDA RPGRIP1 RPSA SETDB1 SQSTM1	9 interacting genes: FBXO7 RBMX RBMY1A1 RBMY1F SHBG SRPK2 SUN2 TRAF3 TRIB3
Entrez ID		57761	27350
HPRD ID		09836	09671
Ensembl ID		ENSG00000101255	ENSG00000244509
Uniprot IDs		B4DMM9 J3KR25 Q96RU7	Q9NRW3
PDB IDs			3VM8 3VOW
Enriched GO Terms of Interacting Partners?
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