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SQSTM1 and VANGL2
Number of citations of the paper that reports this interaction (PubMedID
26754771
)
27
Data Source:
BioGRID
(affinity chromatography technology, pull down, affinity chromatography technology)
SQSTM1
VANGL2
Description
sequestosome 1
VANGL planar cell polarity protein 2
Image
No pdb structure
GO Annotations
Cellular Component
Phagophore Assembly Site
P-body
Nucleoplasm
Cytoplasm
Mitochondrion
Late Endosome
Autophagosome
Endoplasmic Reticulum
Cytosol
Inclusion Body
Aggresome
PML Body
Sarcomere
Intracellular Membrane-bounded Organelle
Amphisome
Autolysosome
Extracellular Exosome
Sperm Midpiece
Lewy Body
Stress Fiber
Plasma Membrane
Cell-cell Junction
Integral Component Of Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
COPII-coated ER To Golgi Transport Vesicle
Cell Pole
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Kinase C Binding
Protein Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Ionotropic Glutamate Receptor Binding
SH2 Domain Binding
Identical Protein Binding
Ubiquitin Binding
Protein-containing Complex Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Autophagy Of Mitochondrion
Mitophagy
Positive Regulation Of Protein Phosphorylation
Immune System Process
Response To Ischemia
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
Autophagy
Apoptotic Process
Mitochondrion Organization
Endosome Organization
Protein Localization
Regulation Of Mitochondrion Organization
Endosomal Transport
Macroautophagy
Cell Differentiation
Negative Regulation Of Protein Ubiquitination
Intracellular Signal Transduction
Aggrephagy
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Ras Protein Signal Transduction
Regulation Of Protein Complex Stability
Selective Autophagy
Interleukin-1-mediated Signaling Pathway
Response To Mitochondrial Depolarisation
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Protein Localization To Plasma Membrane
Protein Localization To Perinuclear Region Of Cytoplasm
Establishment Of Planar Polarity
Neural Tube Closure
Hair Follicle Development
Heart Looping
Membranous Septum Morphogenesis
Muscular Septum Morphogenesis
Planar Cell Polarity Pathway Involved In Axis Elongation
Rho Protein Signal Transduction
Anterior/posterior Pattern Specification
Heparan Sulfate Proteoglycan Biosynthetic Process
Convergent Extension Involved In Neural Plate Elongation
Regulation Of Wnt Signaling Pathway
Glomerulus Development
Regulation Of Actin Cytoskeleton Organization
Somatic Stem Cell Population Maintenance
Cell Migration Involved In Kidney Development
Post-anal Tail Morphogenesis
Dopaminergic Neuron Axon Guidance
Serotonergic Neuron Axon Guidance
Wound Healing
Positive Regulation Of JUN Kinase Activity
Apical Protein Localization
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Somatic Stem Cell Division
Establishment Of Body Hair Planar Orientation
Digestive Tract Morphogenesis
Convergent Extension Involved In Axis Elongation
Inner Ear Receptor Cell Stereocilium Organization
Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis
Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis
Lateral Sprouting Involved In Lung Morphogenesis
Kidney Morphogenesis
Planar Cell Polarity Pathway Involved In Heart Morphogenesis
Cochlea Morphogenesis
Establishment Of Planar Polarity Involved In Neural Tube Closure
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Planar Cell Polarity Pathway Involved In Axon Guidance
Non-motile Cilium Assembly
Pathways
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Pink/Parkin Mediated Mitophagy
Interleukin-1 signaling
Pexophagy
PCP/CE pathway
Asymmetric localization of PCP proteins
Drugs
Diseases
Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS
Alzheimer's disease (late onset) (
24162737
)
Cognitive performance (
19734545
)
Multiple sclerosis (
31604244
24076602
)
Systemic lupus erythematosus (
28714469
)
Interacting Genes
98 interacting genes:
ATXN3
BCL2
BMPR1B
BPTF
BRCA1
CALCR
CALM1
CAMK2A
CCNB1
CDC6
CDK1
CRBN
CRYAB
CSNK1A1
CSNK2A1
DAZAP2
DNAI1
DNAI2
DNAJC10
EEF1D
FKBP4
GABARAP
GABARAPL1
GABARAPL2
GABRR1
GABRR2
GEMIN4
GRB14
GRIA1
GRIA2
GRIA3
HSPB1
IRAK1
ISG15
KCNAB2
LCK
LRRK2
MALT1
MAP1LC3B
MAP1LC3C
MAP2K5
MAPK13
MAPK14
MAPT
MBP
MEIS2
MLH1
MTDH
NBR1
NCOR1
NR2F2
NTRK1
NTRK2
NTRK3
OPTN
PADI1
PAWR
PIK3CA
PIK3R1
PPHLN1
PRKCD
PRKCI
PRKCZ
RAD23A
RAD54L2
RELN
RIPK1
RNF166
RNF168
RPL37
SMAD1
SMAD2
SMAD3
SMAD4
SMURF1
SNCA
STXBP1
TBK1
TGFBR1
TKT
TOE1
TP53INP1
TRAF6
TRIB3
TRIM21
TRIM55
TRIM63
TTN
UBA52
UBB
UBC
UBE2D2
UBE2D3
ULK2
VANGL2
WDR81
XIAP
YWHAZ
5 interacting genes:
AP1M1
ARFRP1
DVL1
MAGI3
SQSTM1
Entrez ID
8878
57216
HPRD ID
03319
02758
Ensembl ID
ENSG00000161011
ENSG00000162738
Uniprot IDs
Q13501
A8K4L6
Q9ULK5
PDB IDs
1Q02
2JY7
2JY8
2K0B
2KNV
4MJS
4UF8
4UF9
5YP7
5YP8
5YPA
5YPB
5YPC
5YPE
5YPF
5YPG
5YPH
6MJ7
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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