TRIB3 and RBM4

Number of citations of the paper that reports this interaction (PubMedID 18276110)
13

Data Source:
BioGRID (two hybrid)

		TRIB3	RBM4
Description		tribbles pseudokinase 3	RNA binding motif protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Speck
	Molecular Function	Transcription Corepressor Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity	RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Zinc Ion Binding Cyclin Binding MiRNA Binding Pre-mRNA Intronic Binding Pre-mRNA Intronic Pyrimidine-rich Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Regulation Of Autophagy Regulation Of Glucose Transmembrane Transport Regulation Of Lipid Metabolic Process Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Regulation Of MAP Kinase Activity Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Kinase B Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress	Regulation Of Alternative MRNA Splicing, Via Spliceosome Cap-independent Translational Initiation IRES-dependent Translational Initiation Of Linear MRNA RNA Processing Negative Regulation Of Translation Cell Differentiation Negative Regulation Of Translation In Response To Stress MiRNA Mediated Inhibition Of Translation Entrainment Of Circadian Clock By Photoperiod MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Translational Initiation Response To Arsenic-containing Substance Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Muscle Cell Differentiation Circadian Regulation Of Translation
Pathways		PIP3 activates AKT signaling Activation of AKT2 PPARA activates gene expression Negative regulation of the PI3K/AKT network CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	Circadian Clock
Drugs
Diseases
GWAS		Information processing speed ( 21130836) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321)	Bipolar disorder ( 21926972)
Interacting Genes		28 interacting genes: AKT1 AKT2 APOBEC3A APOBEC3C APP ATF4 BMPR2 COPS6 DDIT3 EEF1G FBXO7 GDF9 GIT1 HLA-B KAT5 MDFI PML PRMT5 PSMA3 RARA RBM4 RBM48 RELA RIDA RPGRIP1 RPSA SETDB1 SQSTM1	31 interacting genes: AQR CCNA1 CDK2 CXorf56 DDX17 DDX5 DHX9 ESS2 HNRNPF HNRNPH2 HNRNPH3 HNRNPK HNRNPM HNRNPUL1 KLHL41 LRP2BP MAPK8IP2 PABPC1 PRPF31 PTBP2 RBM10 RBM22 RBM23 RBM42 RBM7 SF1 SF3B4 SMAD5 SNRPC TRIB3 U2AF2
Entrez ID		57761	5936
HPRD ID		09836	03982
Ensembl ID		ENSG00000101255	ENSG00000173933
Uniprot IDs		B4DMM9 J3KR25 Q96RU7	Q9BWF3
PDB IDs			2DNQ
Enriched GO Terms of Interacting Partners?
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