LDB1 and LHX3

Number of citations of the paper that reports this interaction (PubMedID 12642495)
41

Data Source:
HPRD (in vitro)

		LDB1	LHX3
Description		LIM domain binding 1	LIM homeobox 3
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cell Leading Edge Protein-containing Complex Beta-catenin-TCF Complex	Nuclear Chromatin Nucleus Transcription Factor Complex
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Transcription Corepressor Activity Protein Binding Enzyme Binding LIM Domain Binding Protein Homodimerization Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organism Development Neuron Differentiation Regulation Of Cell Migration Regulation Of DNA-templated Transcription, Elongation Regulation Of Kinase Activity Histone H3-K4 Acetylation Negative Regulation Of Erythrocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hemoglobin Biosynthetic Process Regulation Of Focal Adhesion Assembly Regulation Of Hematopoietic Stem Cell Differentiation	Placenta Development Motor Neuron Axon Guidance Animal Organ Morphogenesis Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Specification Medial Motor Column Neuron Differentiation Spinal Cord Association Neuron Differentiation Pituitary Gland Development Neuron Differentiation Lung Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of expression of SLITs and ROBOs	Regulation of expression of SLITs and ROBOs
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Pulse pressure ( 30578418)	Atrial fibrillation ( 30061737) Crohn's disease ( 28067908) Free thyroxine concentration ( 25743335) Height ( 28552196 20189936) Inflammatory bowel disease ( 28067908) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 28166213 26635082) Thyroid hormone levels ( 23408906) Ulcerative colitis ( 28067908)
Interacting Genes		27 interacting genes: ATXN1 CTDSP1 DNMT3L ESR1 IRAK3 ISL1 LHX2 LHX3 LHX8 LMO1 LMO2 LMO3 LMO4 LMX1A LMX1B LSM7 POLR1B PSMA1 PSMD10 RLIM SP1 SSBP1 SSBP2 SSBP3 SSBP4 TOLLIP UPF1	8 interacting genes: CITED2 IFT172 ISL1 ISL2 LDB1 LHX1 LMX1A RLIM
Entrez ID		8861	8022
HPRD ID		09144	02783
Ensembl ID		ENSG00000198728	ENSG00000107187
Uniprot IDs		Q86U70	F1T0D5 F1T0D9 Q9UBR4
PDB IDs		2XJY 2XJZ 2YPA
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?