LHX3 and ISL2

Number of citations of the paper that reports this interaction (PubMedID 9452425)
54

Data Source:
HPRD (in vitro, in vivo)

		LHX3	ISL2
Description		LIM homeobox 3	ISL LIM homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex	Nuclear Chromatin Nucleus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Metal Ion Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Placenta Development Motor Neuron Axon Guidance Animal Organ Morphogenesis Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Specification Medial Motor Column Neuron Differentiation Spinal Cord Association Neuron Differentiation Pituitary Gland Development Neuron Differentiation Lung Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development	Regulation Of Transcription By RNA Polymerase II Axonogenesis Spinal Cord Motor Neuron Cell Fate Specification Visceral Motor Neuron Differentiation Retinal Ganglion Cell Axon Guidance Negative Regulation Of Neuron Differentiation Neuron Fate Specification Neuron Development Peripheral Nervous System Neuron Development
Pathways		Regulation of expression of SLITs and ROBOs
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Atrial fibrillation ( 30061737) Crohn's disease ( 28067908) Free thyroxine concentration ( 25743335) Height ( 28552196 20189936) Inflammatory bowel disease ( 28067908) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 28166213 26635082) Thyroid hormone levels ( 23408906) Ulcerative colitis ( 28067908)	Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31015462)
Interacting Genes		8 interacting genes: CITED2 IFT172 ISL1 ISL2 LDB1 LHX1 LMX1A RLIM	2 interacting genes: ISL1 LHX3
Entrez ID		8022	64843
HPRD ID		02783	11053
Ensembl ID		ENSG00000107187	ENSG00000159556
Uniprot IDs		F1T0D5 F1T0D9 Q9UBR4	Q96A47
PDB IDs
Enriched GO Terms of Interacting Partners?
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