LDB1 and LHX8

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		LDB1	LHX8
Description		LIM domain binding 1	LIM homeobox 8
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cell Leading Edge Protein-containing Complex Beta-catenin-TCF Complex	Nuclear Chromatin Female Germ Cell Nucleus Nucleus
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Transcription Corepressor Activity Protein Binding Enzyme Binding LIM Domain Binding Protein Homodimerization Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organism Development Neuron Differentiation Regulation Of Cell Migration Regulation Of DNA-templated Transcription, Elongation Regulation Of Kinase Activity Histone H3-K4 Acetylation Negative Regulation Of Erythrocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hemoglobin Biosynthetic Process Regulation Of Focal Adhesion Assembly Regulation Of Hematopoietic Stem Cell Differentiation	Learning Or Memory Female Gonad Development Forebrain Neuron Development Neuron Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Pulse pressure ( 30578418)
Interacting Genes		27 interacting genes: ATXN1 CTDSP1 DNMT3L ESR1 IRAK3 ISL1 LHX2 LHX3 LHX8 LMO1 LMO2 LMO3 LMO4 LMX1A LMX1B LSM7 POLR1B PSMA1 PSMD10 RLIM SP1 SSBP1 SSBP2 SSBP3 SSBP4 TOLLIP UPF1	8 interacting genes: AXIN1 CRK KLF3 LDB1 NUTM1 PLCG2 SCYL3 SUV39H1
Entrez ID		8861	431707
HPRD ID		09144	17275
Ensembl ID		ENSG00000198728	ENSG00000162624
Uniprot IDs		Q86U70	Q68G74
PDB IDs		2XJY 2XJZ 2YPA
Enriched GO Terms of Interacting Partners?
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