LHX3 and LMX1A

Number of citations of the paper that reports this interaction (PubMedID 9452425)
54

Data Source:
BioGRID (pull down, affinity chromatography technology)

		LHX3	LMX1A
Description		LIM homeobox 3	LIM homeobox transcription factor 1 alpha
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex	Nuclear Chromatin Nucleus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Metal Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	Placenta Development Motor Neuron Axon Guidance Animal Organ Morphogenesis Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Specification Medial Motor Column Neuron Differentiation Spinal Cord Association Neuron Differentiation Pituitary Gland Development Neuron Differentiation Lung Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development	Regulation Of Cell Growth Axon Guidance Memory Locomotory Behavior Dentate Gyrus Development Cerebellum Development Neuron Differentiation Olfactory Behavior Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Synapse Organization Dopaminergic Neuron Differentiation Midbrain Dopaminergic Neuron Differentiation
Pathways		Regulation of expression of SLITs and ROBOs
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Atrial fibrillation ( 30061737) Crohn's disease ( 28067908) Free thyroxine concentration ( 25743335) Height ( 28552196 20189936) Inflammatory bowel disease ( 28067908) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 28166213 26635082) Thyroid hormone levels ( 23408906) Ulcerative colitis ( 28067908)	Alcohol consumption (drinks per week) ( 30679032) Diffusing capacity of the lung for carbon monoxide traits ( 30049742) Macular thickness ( 30535121) Pursuit maintenance gain ( 29064472) Response to acetaminophen (hepatotoxicity) ( 21177773) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Vestibular neuritis ( 30079052)
Interacting Genes		8 interacting genes: CITED2 IFT172 ISL1 ISL2 LDB1 LHX1 LMX1A RLIM	5 interacting genes: BMPR2 ISL1 LDB1 LHX3 TCF3
Entrez ID		8022	4009
HPRD ID		02783	02623
Ensembl ID		ENSG00000107187	ENSG00000162761
Uniprot IDs		F1T0D5 F1T0D9 Q9UBR4	Q8TE12
PDB IDs
Enriched GO Terms of Interacting Partners?
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