CBLB and SH3KBP1

Number of citations of the paper that reports this interaction (PubMedID 12218189)
40

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vivo)

		CBLB	SH3KBP1
Description		Cbl proto-oncogene B	SH3 domain containing kinase binding protein 1
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Membrane Raft	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Endocytic Vesicle Cytoplasmic Vesicle Membrane Neuron Projection Synapse
	Molecular Function	Phosphotyrosine Residue Binding Calcium Ion Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Activity	Protein Binding SH3 Domain Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Axon Guidance Regulation Of Cell Shape Cell Migration Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of B Cell Activation Membrane Organization
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Antipsychotic drug-induced weight gain in schizophrenia or autism ( 31447353) Estimated glomerular filtration rate ( 31152163) Itch intensity from mosquito bite ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 20453840 28445677) Waist circumference ( 31647587) Zinc levels ( 26025379)
Interacting Genes		46 interacting genes: APPL1 ARHGEF7 BLNK CD2AP CRK CRKL CRY1 DAPK1 DUXAP9 EGFR FLT3 FYB1 FYN GLRX3 GORASP2 GRAP2 GRB2 HNRNPK KIT LRRK1 LRRK2 MFHAS1 NCK1 NCK2 NEDD4 NEDD8 PIK3R1 PLCG2 PRMT2 RET RNF11 SH3KBP1 SHC1 SORBS3 SP7 SPRY2 SYK TGFB1I1 TNFRSF11A UBASH3B UBC UBE2D2 UBE2L3 VAV1 VAV2 ZAP70	44 interacting genes: ABI2 ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CD2 GRB2 HCK INPP5D ITSN2 MVB12A NEDD4 PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 UBB UBC UBE2I ZBTB7B ZNF219
Entrez ID		868	30011
HPRD ID		05136	02301
Ensembl ID		ENSG00000114423	ENSG00000147010
Uniprot IDs		B3KSS7 B4DYP3 B7ZAG1 H0Y3L9 Q13191	B7Z6E8 Q5JPT6 Q96B97
PDB IDs		2AK5 2BZ8 2DO6 2J6F 2JNH 2LDR 2OOA 2OOB 3PFV 3VGO 3ZNI	2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS
Enriched GO Terms of Interacting Partners?
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