CBLB and LRRK1

Number of citations of the paper that reports this interaction (PubMedID 29513927)
4

Data Source:
BioGRID (pull down)

		CBLB	LRRK1
Description		Cbl proto-oncogene B	leucine rich repeat kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Membrane Raft	Mitochondrion Cytosol
	Molecular Function	Phosphotyrosine Residue Binding Calcium Ion Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding Metal Ion Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway	Protein Phosphorylation Osteoclast Development Bone Resorption Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Antipsychotic drug-induced weight gain in schizophrenia or autism ( 31447353) Estimated glomerular filtration rate ( 31152163) Itch intensity from mosquito bite ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 20453840 28445677) Waist circumference ( 31647587) Zinc levels ( 26025379)	Central corneal thickness ( 28171582 31798171 29760442) Corneal structure ( 23291589) Height ( 28552196)
Interacting Genes		46 interacting genes: APPL1 ARHGEF7 BLNK CD2AP CRK CRKL CRY1 DAPK1 DUXAP9 EGFR FLT3 FYB1 FYN GLRX3 GORASP2 GRAP2 GRB2 HNRNPK KIT LRRK1 LRRK2 MFHAS1 NCK1 NCK2 NEDD4 NEDD8 PIK3R1 PLCG2 PRMT2 RET RNF11 SH3KBP1 SHC1 SORBS3 SP7 SPRY2 SYK TGFB1I1 TNFRSF11A UBASH3B UBC UBE2D2 UBE2L3 VAV1 VAV2 ZAP70	53 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CHGB CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SELENOS SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TEX33 TIRAP TM2D3 VGLL4
Entrez ID		868	79705
HPRD ID		05136	14319
Ensembl ID		ENSG00000114423	ENSG00000154237
Uniprot IDs		B3KSS7 B4DYP3 B7ZAG1 H0Y3L9 Q13191	Q38SD2
PDB IDs		2AK5 2BZ8 2DO6 2J6F 2JNH 2LDR 2OOA 2OOB 3PFV 3VGO 3ZNI
Enriched GO Terms of Interacting Partners?
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