EIF4G3 and VAV2

Number of citations of the paper that reports this interaction (PubMedID 18654987)
16

Data Source:
BioGRID (two hybrid)

		EIF4G3	VAV2
Description		eukaryotic translation initiation factor 4 gamma 3	vav guanine nucleotide exchange factor 2
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex	Cytosol Plasma Membrane
	Molecular Function	RNA Cap Binding RNA Binding MRNA Binding Translation Initiation Factor Activity Translation Factor Activity, RNA Binding	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding
	Biological Process	Translational Initiation Regulation Of Translational Initiation Negative Regulation Of Autophagy	Angiogenesis Signal Transduction G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Size Cell Migration Lamellipodium Assembly Platelet Activation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction
Pathways		ISG15 antiviral mechanism	GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) General risk tolerance (MTAG) ( 30643258) Morning person ( 30696823) Postoperative acute renal failure after cardiac surgery ( 30678657) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Superior frontal gyrus grey matter volume ( 25335168)	Central corneal thickness ( 29760442) Corneal astigmatism ( 30306274) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Multiple sclerosis ( 20598377) Pre-treatment viral load in HIV-1 infection ( 31219150) vWF and FVIII levels ( 21810271)
Interacting Genes		8 interacting genes: CAMK1 EIF4A1 EIF4E HSPB1 LIG4 MKNK1 PABPC1 VAV2	64 interacting genes: ARIH1 BIRC6 BOD1L1 BRDT BZW1 CAV1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 FNTA FUCA1 FYN GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MED21 MRGBP NCKAP5 NEK3 NUP214 PHF10 PNMA1 POGZ PPM1B PRLR RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 STOM SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1
Entrez ID		8672	7410
HPRD ID		06802	02694
Ensembl ID		ENSG00000075151	ENSG00000160293
Uniprot IDs		A0A0A0MSA7 O43432 Q59GJ0	P52735
PDB IDs		1HU3	2DLZ 2DM1 2LNW 2LNX 4ROJ
Enriched GO Terms of Interacting Partners?
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