EIF4G3 and MKNK1

Number of citations of the paper that reports this interaction (PubMedID 9878069)
201

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, in vivo)

		EIF4G3	MKNK1
Description		eukaryotic translation initiation factor 4 gamma 3	MAPK interacting serine/threonine kinase 1
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Cap Binding RNA Binding MRNA Binding Translation Initiation Factor Activity Translation Factor Activity, RNA Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Metal Ion Binding
	Biological Process	Translational Initiation Regulation Of Translational Initiation Negative Regulation Of Autophagy	Regulation Of Translation Protein Phosphorylation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation
Pathways		ISG15 antiviral mechanism	Spry regulation of FGF signaling
Drugs
Diseases
GWAS		Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) General risk tolerance (MTAG) ( 30643258) Morning person ( 30696823) Postoperative acute renal failure after cardiac surgery ( 30678657) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Superior frontal gyrus grey matter volume ( 25335168)	Schizophrenia ( 26198764) Triglyceride levels ( 31170924)
Interacting Genes		8 interacting genes: CAMK1 EIF4A1 EIF4E HSPB1 LIG4 MKNK1 PABPC1 VAV2	26 interacting genes: APP ATXN3 CREBBP DDAH2 DNAJC7 EIF4E EIF4G1 EIF4G2 EIF4G3 FANCA HGS HIPK2 HSP90AB1 MAPK1 MAPK14 MAPK3 MBP PABPC4 PAK2 PHAX PLA2G4A PRKDC RCN3 SPRY2 TNIP2 UBE2D1
Entrez ID		8672	8569
HPRD ID		06802	09468
Ensembl ID		ENSG00000075151	ENSG00000079277
Uniprot IDs		A0A0A0MSA7 O43432 Q59GJ0	A8K341 Q7Z319 Q9BUB5
PDB IDs		1HU3	2HW6 2Y9Q 5WVD
Enriched GO Terms of Interacting Partners?
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